catalog number :
MBS8502323
products full name :
E-cadherin Antibody
products short name :
[E-cadherin]
other names :
[cadherin-1 preproprotein; Cadherin-1; cadherin-1; cadherin 1; ARC-1; Epithelial cadherin; E-cadherin]
other gene names :
[Cdh1; Cdh1; Um; UVO; Ecad; ARC-1; E-cad; L-CAM; AA960649; E-cadherin]
image1 heading :
Immunohistochemistry
image2 heading :
Western Blot
ncbi acc num :
NP_033994.1
ncbi gb acc num :
NM_009864.3
ncbi mol weight :
98,256 Da
ncbi pathways :
Adherens Junction Pathway (83267); Adherens Junction Pathway (481); Adherens Junctions Interactions Pathway (1323791); Apoptosis Pathway (1323524); Apoptotic Cleavage Of Cell Adhesion Proteins Pathway (1323551); Apoptotic Cleavage Of Cellular Proteins Pathway (1323549); Apoptotic Execution Phase Pathway (1323548); Bacterial Invasion Of Epithelial Cells Pathway (149817); Bacterial Invasion Of Epithelial Cells Pathway (148661); Bladder Cancer Pathway (83308)
ncbi summary :
This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related cadherin gene on chromosome 8. [provided by RefSeq, Oct 2015]
uniprot summary :
Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 ().