antibody

ASGR1 Antibody

MBS8502254

0.1 mg

290 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

ASGR1 Antibody

ASGR1

asialoglycoprotein receptor 1 isoform b; Asialoglycoprotein receptor 1; asialoglycoprotein receptor 1; hepatic lectin H1; C-type lectin domain family 4 member H1; asialoglycoprotein receptor 1; C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1

ASGR1

ASGR1; ASGR1; HL-1; ASGPR; ASGPR1; CLEC4H1; CLEC4H1; ASGP-R 1; ASGPR 1; HL-1

ASGR1_HUMAN

Polyclonal

Rabbit

Human

252

Lyophilized ASGR1 antibody purified by protein affinity column containing 1% BSA and 0.02% NaN3

100ug/200ul

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/thaw cycles.

ELISA (EIA), Western Blot (WB)

ELISA titer: 1:20,000-1:80,000. Western blot analysis: 1:500-1:1,000. Optimal dilutions/concentrations should be determined by the end user.

Source Note: Rabbit polyclonal ASGR1 (1) antibody was raised against a recombinate human ASGR1 protein 96-283aa (BC032130). Reactivity Note: Predicted: Mouse, Rat; Not yet tested in other species.

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

(1) Onizuka,T., Shimizu,H., Moriwaki,Y., et al. NMR study of ligand release from asialoglycoprotein receptor under solution conditions in early endosomes. FEBS J. 279 (15), 2645-2656 (2012)

308387363

BC032130

NM_001197216.2

29,144 Da

Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541)

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

ASGR1: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 17p13.2. Cellular Component: integral to plasma membrane; extracellular region. Molecular Function: protein binding; protein homodimerization activity; metal ion binding; asialoglycoprotein receptor activity; carbohydrate binding. Biological Process: receptor-mediated endocytosis; cellular response to extracellular stimulus

0.1 mg

290 USD