PDX1 Antibody | MyBioSource MBS8502240 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PDX1 Antibody

catalog :

MBS8502240

quantity :

0.1 mL

price :

310 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of various celllines, using PDX1antibody.

image 2 :

image 3 :

Immunohistochemistryof paraffin-embeddedhuman gastric tissue usingPDX1antibody.

product information

catalog number :

MBS8502240

products type :

Antibody

products full name :

PDX1 Antibody

products short name :

[PDX1]

products name syn :

[GSF; IPF1; IUF1; IDX-1; MODY4; PDX-1; STF-1]

other names :

[pancreas/duodenum homeobox protein 1; Pancreas/duodenum homeobox protein 1; pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox 1; Glucose-sensitive factor; GSF; Insulin promoter factor 1; IPF-1; Insulin upstream factor 1; IUF-1; Islet/duodenum homeobox-1; IDX-1; Somatostatin-transactivating factor 1; STF-1]

products gene name :

[PDX1]

other gene names :

[PDX1; PDX1; GSF; IPF1; IUF1; IDX-1; MODY4; PDX-1; STF-1; PAGEN1; IPF1; STF1; PDX-1; GSF; IPF-1; IUF-1; IDX-1; STF-1]

clonality :

polyclonal

isotype :

IgG

host :

rabbit

reactivity :

Human, Mouse, Rat

sequence length :

283

purity :

Affinity purification

storage stability :

Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500-1:1000. IHC: 1:50-1:100

image1 heading :

Western Blot (WB)

image2 heading :

Testing Data

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: A synthetic peptide of human PDX1. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

products categories :

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

products description :

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

ncbi gi num :

4557673

ncbi acc num :

NP_000200.1

ncbi gb acc num :

NM_000209.3

uniprot acc num :

P52945

ncbi mol weight :

31kDa

ncbi pathways :

Developmental Biology Pathway (477129); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Insulin Secretion Pathway (777534); Maturity Onset Diabetes Of The Young Pathway (83096); Maturity Onset Diabetes Of The Young Pathway (508); Regulation Of Beta-cell Development Pathway (106328); Regulation Of Gene Expression In Beta Cells Pathway (106332); Regulation Of Gene Expression In Early Pancreatic Precursor Cells Pathway (106329); Type II Diabetes Mellitus Pathway (83094); Type II Diabetes Mellitus Pathway (198791)

ncbi summary :

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Aug 2017]

uniprot summary :

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

size1 :

0.1 mL

price1 :

310 USD

more info or order :

MyBioSource product webpage