product summary
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company name :
MyBioSource
product type :
antibody
product name :
TRIB3 Antibody
catalog :
MBS8501685
quantity :
0.1 mL
price :
310 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
image
image 1 :
Western blot analysis of extracts of mouse livercell lines, using TRIB3 antibody.
product information
catalog number :
MBS8501685
products type :
Antibody
products full name :
TRIB3 Antibody
products short name :
[TRIB3]
products name syn :
[C20orf97; NIPK; SINK; SKIP3; TRB3]
other names :
[tribbles homolog 3 isoform 1; Tribbles homolog 3; tribbles homolog 3; tribbles pseudokinase 3; Neuronal cell death-inducible putative kinase; SINK; p65-interacting inhibitor of NF-kappa-B]
products gene name :
[TRIB3]
other gene names :
[TRIB3; TRIB3; NIPK; SINK; TRB3; SKIP3; C20orf97; C20orf97; NIPK; SKIP3; TRB3; TRB-3]
clonality :
polyclonal
isotype :
IgG
host :
rabbit
reactivity :
Human, Mouse, Rat
sequence length :
358
purity :
Affinity purification
storage stability :
Store at -20°C or -80°C. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:500-1:1000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Fusion protein of human TRIB3. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
other info2 :
Calculated MW: 40kDa
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products description :
Tribbles homolog 3 (TRIB3) is a pseudokinase involved in the regulation of several signaling pathways involved in cell survival and/or cell stress.Whereas mRNA levels of TRIB3 are related with a poor prognosis, TRIB3 protein is associated with a good prognosis in human breast cancer patients, possibly due to the fact that TRIB3 is involved in hypoxia tolerance(PMID:21704407). This antibody is specific to TRIB3.
ncbi gi num :
668259463
ncbi acc num :
NP_001288117.1
ncbi gb acc num :
NM_001301188.1
uniprot acc num :
Q96RU7
ncbi mol weight :
40kDa
ncbi pathways :
Activation Of AKT2 Pathway (1269433); Adaptive Immune System Pathway (1269171); Adipogenesis Pathway (198832); CD28 Co-stimulation Pathway (1269178); CD28 Dependent PI3K/Akt Signaling Pathway (1269179); Costimulation By The CD28 Family Pathway (1269177); DAP12 Interactions Pathway (1269283); DAP12 Signaling Pathway (1269284); Downstream Signal Transduction Pathway (1269479); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (1269185)
ncbi summary :
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
uniprot summary :
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.
size1 :
0.1 mL
price1 :
310 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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