catalog number :
MBS8501473
products full name :
SLN Antibody
products short name :
[SLN]
products name syn :
[Sarcolipin]
other names :
[sarcolipin; Sarcolipin; sarcolipin; sarcolipin]
products gene name :
[SLN]
other gene names :
[SLN; SLN]
reactivity :
Human, Mouse, Rat.
specificity :
SLN Antibody detects endogenous levels of total SLN.
purity :
Immunogen affinity purified.
form :
Rabbit IgG in phosphate buffered saline, pH 7.4 150 mM NaCI, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20°C. Stable for 12 months from date of receipt.
app notes :
WB 1:500-1:2000
image1 heading :
Western blot
other info1 :
Immunogen: KLH-conjugated linear peptide corresponding to the C-termius of human Sarcopilin
products description :
SALN (Sarcolipin) is a Protein Coding gene. Diseases associated with SLN include Familial Atrial Fibrillation. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Cardiac conduction.
ncbi acc num :
NP_003054.1
ncbi gb acc num :
NM_003063.2
ncbi mol weight :
~6 kDa observed. An uncharacterized band may be observed at ~13kDa in some tissue lysates.
ncbi pathways :
Cardiac Conduction Pathway (1339115); Ion Channel Transport Pathway (1269950); Ion Homeostasis Pathway (1339121); Ion Transport By P-type ATPases Pathway (1269951); Muscle Contraction Pathway (1269868); Transmembrane Transport Of Small Molecules Pathway (1269903)
ncbi summary :
Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]
uniprot summary :
Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis ().