DDR2 Antibody | MyBioSource MBS850146 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

DDR2 Antibody

catalog :

MBS850146

quantity :

0.1 mg

price :

290 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3B11E4

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS850146

products type :

Antibody

products full name :

DDR2 Antibody

products short name :

DDR2

products name syn :

TKT; MIG20a; NTRKR3; TYRO10

other names :

discoidin domain-containing receptor 2; Discoidin domain-containing receptor 2; discoidin domain-containing receptor 2; tyrosylprotein kinase; hydroxyaryl-protein kinase; discoidin domain receptor 2; tyrosine-protein kinase TYRO10; CD167 antigen-like family member B; cell migration-inducing protein 20; migration-inducing gene 16 protein; receptor protein-tyrosine kinase TKT; discoidin domain receptor family, member 2; neurotrophic tyrosine kinase receptor related 3; neurotrophic tyrosine kinase, receptor-related 3; discoidin domain-containing receptor tyrosine kinase 2; discoidin domain receptor tyrosine kinase 2; CD167 antigen-like family member B; Discoidin domain-containing receptor tyrosine kinase 2; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10; CD_antigen: CD167b

products gene name :

DDR2

other gene names :

DDR2; DDR2; TKT; MIG20a; NTRKR3; TYRO10; NTRKR3; TKT; TYRO10; Discoidin domain receptor 2

uniprot entry name :

DDR2_HUMAN

clonality :

Monoclonal

clone :

3B11E4

host :

Mouse

reactivity :

Human

sequence length :

855

form :

Ascitic fluid containing 0.03% sodium azide.

concentration :

100ug/100ul

storage stability :

Store at 4 degree C. For long term storage, store at -20 degree C

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

app notes :

WB: 1/500 - 1/2000, IHC:1/200 - 1/1000, IF: 1/200 - 1/1000, ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.

other info2 :

Immunogen: Purified recombinant fragment of human DDR2 expressed in E. Coli. Species: Mouse IgG2a

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

ncbi gi num :

62420886

ncbi acc num :

NP_001014796.1

ncbi gb acc num :

NM_001014796.1

ncbi mol weight :

96,736 Da

ncbi pathways :

Endochondral Ossification Pathway 198812!!Extracellular Matrix Organization Pathway 576262!!Non-integrin Membrane-ECM Interactions Pathway 833810

ncbi summary :

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

size :

0.1 mg

price :

290 USD

more info or order :

MyBioSource product webpage