other

SDCBP Antibody

MBS8501272

0.1 mg

300 USD

Antibody

SDCBP Antibody

[SDCBP]

[syntenin-1 isoform 1; Syntenin-1; syntenin-1; syndecan binding protein; Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1]

[SDCBP]

[SDCBP; SDCBP; ST1; MDA9; SYCL; MDA-9; TACIP18; MDA9; SYCL; MDA-9; TACIP18]

298

Western Blot

55749490

NP_001007068.1

NM_001007067.1

O00560

31,762 Da

Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); EPH-Ephrin Signaling Pathway (1127691); Ephrin Signaling Pathway (1127694); IL-5 Signaling Pathway (198770); L1CAM Interactions Pathway (161003); Neurofascin Interactions Pathway (161008); Syndecan-1-mediated Signaling Events Pathway (138046); Syndecan-2-mediated Signaling Events Pathway (138031); Syndecan-4-mediated Signaling Events Pathway (138064)

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017]

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).

0.1 mg

300 USD