catalog number :
MBS8501136
products full name :
IGFBP-2 Antibody
products short name :
[IGFBP-2]
other names :
[insulin-like growth factor-binding protein 2 isoform a; Insulin-like growth factor-binding protein 2; insulin-like growth factor-binding protein 2; insulin like growth factor binding protein 2]
products gene name :
[IGFBP-2]
other gene names :
[IGFBP2; IGFBP2; IBP2; IGF-BP53; BP2; IBP2; IBP-2; IGF-binding protein 2; IGFBP-2]
image1 heading :
Western Blot
ncbi acc num :
NP_000588.2
ncbi gb acc num :
NM_000597.2
ncbi mol weight :
34,814 Da
ncbi pathways :
Metabolism Of Proteins Pathway (106230); Myometrial Relaxation And Contraction Pathways (198759); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)
ncbi summary :
The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
uniprot summary :
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.