antibody

EDN3 Antibody

MBS8501122

0.1 mL

310 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry

Antibody

EDN3 Antibody

[EDN3]

[EDN3; ET3; MGC15067; MGC61498]

[endothelin-3 isoform 4 preproprotein; Endothelin-3; endothelin-3; endothelin 3; Preproendothelin-3; PPET3]

[EDN3]

[EDN3; EDN3; ET3; ET-3; WS4B; HSCR4; PPET3; ET-3; PPET3]

polyclonal

IgG

rabbit

Human, Mouse, Rat

198

Affinity purification

Store at-20°C or-80°C. Avoid freeze/thaw cycles.

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500-1:2000. IHC: 1:50-1:200

Immunogen: Recombinant protein of human EDN3. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

698848571

NP_001289384.1

NM_001302455.1

P14138

26kDa

Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Endothelins Pathway (137958); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); Gastrin-CREB Signalling Pathway Via PKC And MAPK (1269592); Peptide Ligand-binding Receptors Pathway (1269546); Signal Transduction Pathway (1269379); Signaling By GPCR Pathway (1269543)

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Endothelins are endothelium-derived vasoconstrictor peptides.

0.1 mL

310 USD