catalog number :
MBS8501032
products full name :
alpha Lactalbumin Mouse Monoclonal Antibody
products short name :
[alpha Lactalbumin]
other names :
[alpha-lactalbumin; Alpha-lactalbumin; alpha-lactalbumin; lactalbumin alpha; Lactose synthase B protein; Lysozyme-like protein 7]
other gene names :
[LALBA; LALBA; LYZG; LYZL7]
reactivity :
Human, Bovine
specificity :
alpha Lactalbumin Mouse Monoclonal antibody detects endogenous alpha Lactalbumin proteins
form :
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at-20 degree C for 1 year. Do not aliquot the antibody.
tested application :
Western Blot (WB)
image1 heading :
Testing Data
products description :
In primates, alpha-lactalbumin expression is upregulated in response to the hormone prolactin and increases the production of lactose.alpha-Lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta-1, 4-galactosyltransferase (beta4Gal-T1) forms the catalytic component.
ncbi acc num :
NP_002280.1
ncbi gb acc num :
NM_002289.2
ncbi mol weight :
16,225 Da
ncbi pathways :
Galactose Metabolism Pathway (82931); Galactose Metabolism Pathway (292); Metabolic Pathways (132956)
ncbi summary :
This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]
uniprot summary :
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.