catalog number :
MBS8500966
products full name :
PYGB Antibody
products short name :
[PYGB]
other names :
[glycogen phosphorylase, brain form; Glycogen phosphorylase, brain form; glycogen phosphorylase, brain form; glycogen phosphorylase B]
products gene name :
[PYGB]
other gene names :
[PYGB; PYGB; GPBB]
image1 heading :
Western blot
ncbi acc num :
NP_002853.2
ncbi gb acc num :
NM_002862.3
ncbi mol weight :
96,696 Da
ncbi pathways :
Disease Pathway (530764); Glucose Metabolism Pathway (106199); Glycogen Metabolism Pathway (198856); Glycogen Breakdown (glycogenolysis) Pathway (106212); Glycogen Storage Diseases Pathway (980468); Insulin Signaling Pathway (83090); Insulin Signaling Pathway (501); Metabolism Pathway (477135); Metabolism Of Carbohydrates Pathway (106196); Myoclonic Epilepsy Of Lafora Pathway (980469)
ncbi summary :
The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]
uniprot summary :
Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228).