antibody

A1/Bfl-1 Antibody

MBS8500810

0.1 mL

310 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

Antibody

A1/Bfl-1 Antibody

[A1/Bfl-1]

[GRS; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5]

[bcl-2-related protein A1 isoform 2; Bcl-2-related protein A1; bcl-2-related protein A1; BCL2 related protein A1; Bcl-2-like protein 5; Bcl2-L-5; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS]

[A1/Bfl-1]

[BCL2A1; BCL2A1; GRS; ACC1; ACC2; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5; BCL2L5; BFL1; GRS; HBPA1; Bcl2-L-5]

polyclonal

IgG

rabbit

Human, Mouse, Rat

163

Affinity purification

Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

WB: 1:500-1:2000

Western Blot (WB)

Immunogen: Recombinant protein of human BCL2A1. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero-or homodimers and act as anti-and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

168480072

NP_001108207.1

NM_001114735.1

Q16548

20kDa

Apoptosis Modulation And Signaling Pathway (198822); BCR Signaling Pathway (138058); Direct P53 Effectors Pathway (137939); NF-kappa B Signaling Pathway (634527); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 ().

0.1 mL

310 USD