product summary
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company name :
MyBioSource
product type :
antibody
product name :
SETD8 Antibody
catalog :
MBS8500566
quantity :
0.1 mL
price :
310 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry
more info or order :
product information
catalog number :
MBS8500566
products type :
Antibody
products full name :
SETD8 Antibody
products short name :
[SETD8]
products name syn :
[KMT5A; PR-Set7; SET07; SET8]
other names :
[N-lysine methyltransferase KMT5A isoform 2; N-lysine methyltransferase KMT5A; N-lysine methyltransferase KMT5A; lysine methyltransferase 5A; H4-K20-HMTase KMT5A; Histone-lysine N-methyltransferase KMT5A (EC:2.1.1.43); Lysine N-methyltransferase 5A; Lysine-specific methylase 5A]
products gene name :
[SETD8]
other gene names :
[KMT5A; KMT5A; SET8; SET07; SETD8; PR-Set7; PR-Set7; PR/SET07]
clonality :
polyclonal
isotype :
IgG
host :
rabbit
reactivity :
Human, Mouse, Rat
sequence length :
322
purity :
Affinity purification
form :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
storage stability :
Store at -20°C or -80°C. Avoid freeze / thaw cycles
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500-1:2000. IHC: 1:50-1:200
other info1 :
Immunogen: Recombinant protein of human SETD8
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products description :
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.
ncbi gi num :
1027250576
ncbi acc num :
NP_001311433.1
ncbi gb acc num :
NM_001324504.1
uniprot acc num :
Q9NQR1
ncbi mol weight :
43kDa
ncbi pathways :
Cell Cycle Pathway (1269741); Cell Cycle, Mitotic Pathway (1269763); Chromatin Modifying Enzymes Pathway (1270434); Chromatin Organization Pathway (1270433); Condensation Of Prophase Chromosomes Pathway (1269813); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); Histone Modifications Pathway (920986); Lysine Degradation Pathway (82956); Lysine Degradation Pathway (320)
ncbi summary :
The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation. [provided by RefSeq, May 2016]
uniprot summary :
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
size1 :
0.1 mL
price1 :
310 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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