product summary
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company name :
MyBioSource
product type :
antibody
product name :
ATG13 Antibody
catalog :
MBS8500062
quantity :
0.1 mL
price :
310 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS8500062 image 1
Western blot analysis of extracts of variouscell lines, using ATG13 antibody.
product information
catalog number :
MBS8500062
products type :
Antibody
products full name :
ATG13 Antibody
products short name :
[ATG13]
products name syn :
[KIAA0652; ATG13; FLJ20698]
other names :
[autophagy-related protein 13 isoform c; Autophagy-related protein 13; autophagy-related protein 13; autophagy related 13]
products gene name :
[ATG13]
other gene names :
[ATG13; ATG13; KIAA0652; PARATARG8; KIAA0652]
clonality :
polyclonal
isotype :
IgG
host :
rabbit
reactivity :
Human, Mouse, Rat
sequence length :
517
purity :
Affinity purification
storage stability :
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500-1:2000. IHC: 1:50-1:200
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant protein of human ATG13. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
products categories :
Autophagy antibody
products description :
The autophagy-related protein 13 (Atg13) plays an important role in the formation of autophagosomes. Autophagosomes are formed in response to nutrient deprivation and function as the transport vesicles for organelles, proteins, and protein complexes targeted for lysosomes that digest these cargos to produce energy and nutrients. Atg13 is activated by the mTOR pathway and forms a complex with the FIP200 protein. This complex is involved in enhancing the activity of the ULK1 kinase which is required for the formation of autophagosomes. Atg13/FIP200 faciliates the localization of ULK1 to pre-autophagosomes, and subsequently stabilizes ULK1. Autophagy is an important process in development, growth, and cell differentiation, and disruption of this process may contribute to cancer, aging, and neurodegenerative diseases.
ncbi gi num :
218082953
ncbi acc num :
NP_001136145.1
ncbi gb acc num :
NM_001142673.2
uniprot acc num :
O75143
ncbi mol weight :
57kDa
ncbi pathways :
Regulation Of Autophagy Pathway (83058); Regulation Of Autophagy Pathway (468); Senescence And Autophagy Pathway (198780); MTOR Signaling Pathway (138001)
ncbi summary :
The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]
uniprot summary :
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
size1 :
0.1 mL
price1 :
310 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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