Anti-TEAD2 Antibody | MyBioSource MBS846045 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-TEAD2 Antibody

catalog :

MBS846045

quantity :

0.1 mL

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS846045

products type :

Antibody

products full name :

Anti-TEAD2 Antibody

products short name :

[TEAD2]

products name syn :

[TEF4; Transcriptional enhancer factor TEF-4; TEA domain family member 2; TEAD-2]

other names :

[transcriptional enhancer factor TEF-4 isoform 1; Transcriptional enhancer factor TEF-4; transcriptional enhancer factor TEF-4; TEA domain transcription factor 2; TEA domain family member 2; TEAD-2]

products gene name :

[TEAD2]

other gene names :

[TEAD2; TEAD2; ETF; TEF4; TEF-4; TEAD-2; TEF4; TEAD-2]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

450

specificity :

Recognizes endogenous levels of TEAD2 protein.

purity :

The antibody was purified by affinity chromatography.

form :

Liquid. Supplied in 0.42%, Potassium phosphate, 0.87% Sodium chloride; pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipping: Blue ice. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB); Immunohistochemistry (IHC); Immunofluorescence (IF); Immunocytochemistry (ICC)

app notes :

WB: 1:500- 1:2000. IHC: 1:50- 1:200. IF/IC: 1:50- 1:100. ChIP: 1:100- 1:500. Note: This information is only intented as a guide. The optimal dilutions must be determined by the user.

image1 heading :

Testing Data

other info2 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TEAD2

products description :

Polyclonal antibody to detect endogenous levels of TEAD2 in human and mouse. Transcription factor which plays a key role in the Hippo signaling pathway; a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2; in complex with its regulatory protein SAV1; phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1; which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ; thereby regulating cell proliferation; migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

ncbi gi num :

375331915

ncbi acc num :

NP_001243587.1

ncbi gb acc num :

NM_001256658.1

uniprot acc num :

Q15562

ncbi pathways :

Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544); YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway (576276)

uniprot summary :

TEAD2: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'- GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. Interacts with YAP1 and WWTR1/TAZ. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 19q13.33. Cellular Component: cytosol; intracellular membrane-bound organelle; nucleoplasm. Molecular Function: protein binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity. Biological Process: embryonic organ development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein complex assembly; transcription initiation from RNA polymerase II promoter

size1 :

0.1 mL

price1 :

345 USD

more info or order :

MyBioSource product webpage