antibody

ICOS/CD278 Antibody

MBS845959

0.1 mL

210 USD

polyclonal

rabbit

nonconjugated

western blot, flow cytometry, FACS, immunohistochemistry - paraffin section

Antibody

ICOS/CD278 Antibody

[ICOS/CD278]

[Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD278; ICOS; AILIM]

[inducible T-cell costimulator; Inducible T-cell costimulator; inducible T-cell costimulator; inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD_antigen: CD278]

[ICOS/CD278]

[ICOS; ICOS; AILIM; CD278; CVID1; AILIM]

Polyclonal

IgG

Rabbit

Human

This antibody is purified through Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Liquid

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Immunohistochemistry-Paraffin (IHC-P); Flow Cytometry (FC/FACS); Western Blot (WB)

FC: 1:10-51. WB: 1:1000. IHC-P: 1:50-100

Testing Data

Immunogen: KLH conjugated synthetic peptide between 196-225 amino acids from the C-terminal region of human CD27. Formulation: Supplied in PBS with 0.09% (W/V) sodium azide

Immunology

Polyclonal antibody to detect ICOS/CD278 in human samples. ICOS belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling; immune responses; and regulation of cell proliferation.

15029518

NP_036224.1

NM_012092.3

Q9Y6W8

19,127 Da

Adaptive Immune System Pathway (366160); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (119552); Immune System Pathway (106386); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); Primary Immunodeficiency Pathway (83125); Primary Immunodeficiency Pathway (537); T Cell Receptor Signaling Pathway (83080)

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

ICOS: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1). CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q33.2. Cellular Component: plasma membrane. Molecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity. Biological Process: phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade; T cell costimulation. Disease: Immunodeficiency, Common Variable, 1; Immunodeficiency, Common Variable, 2

0.1 mL

210 USD