catalog number :
MBS845421
products type :
Recombinant Protein
products full name :
BD-2, human recombinant
products short name :
[BD-2]
products name syn :
[Skin-antimicrobial peptide 1; SAP1; Beta-defensin 2; Defensin; beta 2; Skin-antimicrobial peptide 1; DEFB4A; DEFB102; DEFB2; DEFB4; DEFB4B]
other names :
[beta-defensin 4B; Beta-defensin 4A; beta-defensin 4B; defensin, beta 4B; Beta-defensin 2; BD-2; hBD-2; Defensin, beta 2; Skin-antimicrobial peptide 1; SAP1]
products gene name :
[DEFB2]
other gene names :
[DEFB4B; DEFB4A; DEFB4P; DEFB102; DEFB2; DEFB4; BD-2; hBD-2; SAP1]
uniprot entry name :
DFB4A_HUMAN
purity :
>98% by SDS-PAGE and HPLC analyses Endotoxin level is <0.1 ng per ug (1EU/ug)
form :
Sterile filtered and lyophilized with no additives
storage stability :
The lyophilized protein is best stored desiccated below 0°C. Reconstituted human BD-2 should be stored at working aliquots at -20°C.
tested application :
SDS-PAGE; HPLC
other info1 :
Reconstitution: Centrifuge the vial prior to opening. Reconstitute in ddH 2 O to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers or store at 4°C for 1 week or -20°C for future use.
other info2 :
Biological activity: Determined by its ability to chemoattract immature human dendritic cells using a concentration of 10-100 ng/mL.
products description :
Background: Recombinant human beta-defensin-2 (BD-2) is an antimicrobial peptide which belongs to the distinct family of beta-defensins. Recombinant human BD-2 is a 4.3 kDa protein containing 41 amino acid residues.
ncbi acc num :
NP_001192195.1
ncbi gb acc num :
NM_001205266.1
ncbi mol weight :
4.3 kDa
ncbi pathways :
Beta Defensins Pathway (1269267); Defensins Pathway (1269265); Immune System Pathway (1269170); Innate Immune System Pathway (1269203)
ncbi summary :
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]
uniprot summary :
defensin, beta 2: Has antibacterial activity (Potential). Belongs to the beta-defensin family. LAP/TAP subfamily. Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8p23.1. Cellular Component: Golgi lumen; extracellular region. Biological Process: G-protein coupled receptor protein signaling pathway; defense response to bacterium; innate immune response; immune response; chemotaxis