catalog number :
MBS845177
products type :
Recombinant Protein
products full name :
MART-1 / Melan-A, mouse recombinant
products short name :
[MART-1/Melan-A]
products name syn :
[Melanoma antigen recognized by T-cells 1; Antigen LB39-AA; Antigen SK29-AA; MART-1; Melan-A]
other names :
[melanoma antigen recognized by T-cells 1; Melan-A; melanoma antigen recognized by T-cells 1; melan-A; Melan-A]
products gene name :
[Melan-A]
other gene names :
[Mlana; Mlana; Mart1; A930034P04Rik]
uniprot entry name :
Q2TA50_MOUSE
sequence :
Full length mouse MART-1
purity :
Monomer (>50%), dimer (30-40%), and ologomers (10-20%), as determined by SDS-PAGE
form :
Liquid. MART-1/Melan-A protein is in 50 mM Tris, pH 7.5, 100 mM NaCl, 20 mM beta-mercaptoethanol, and 20%Glycerol.
storage stability :
Store at -20°C or -80°C in small aliquots . Stable for 12 months.
image1 heading :
Testing Data
other info1 :
Source: E.coli. Endotoxin: Not determined.
products categories :
Proteins and Enzymes; Other Proteins & EnzymesProteins and Enzymes; Proteins and Enzymes (A-Z)
products description :
Background: MART-1 (also known as Melan-A) is a melanocyte differentiation antigen or marker recognized by autologous cytotoxic T lymphocytes. It is a membrane protein with one transmembrane peptide. Melan-A is expressed by a large proportion of melanoma tumors, both melanotic and amelanotic and by melanoma cell lines. It is present in melanocytes of normal skin and retina, nevi and in more than 85% of melanomas. Melan-A/MART-1 is not expressed by non-melanoma malignancies. It is recognized by autologous cytotoxic T lymphocytes. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. Six other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, Tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Mouse MART-1 is purified by proprietary chromatographic techniques.
ncbi acc num :
NP_084269.1
ncbi gb acc num :
NM_029993.1
ncbi mol weight :
17.6 kDa
uniprot summary :
MLANA: Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. Protein type: Cell surface; Membrane protein, integral. Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; melanosome; trans-Golgi network