protein

Bromodomain Testis-specific Protein (BrdT), human recombinant

MBS845099

0.02 mg

200 USD

Recombinant Protein

Bromodomain Testis-specific Protein (BrdT), human recombinant

[Bromodomain Testis-specific Protein (BrdT)]

[BrdT; Cancer/testis antigen 9; CT9; RING3-like protein; Recombinant Human Bromodomain Testis-specific Protein (BrdT)]

[bromodomain testis-specific protein isoform b; Bromodomain testis-specific protein; bromodomain testis-specific protein; bromodomain, testis-specific; Cancer/testis antigen 9; CT9; RING3-like protein]

[BRDT]

[BRDT; BRDT; CT9; BRD6; CT9]

BRDT_HUMAN

E Coli

947

> 98% by SDS-PAGE

rh-BrdT is supplied as a solution in 50 mM Tris, pH 8.0, 150 mM NaCl and 10% Glycerol.

Stable for 1 year at -80°C. Avoid multiple freeze/thaw cycles as activity may decrease.

BrdT useful in studying bromodomain binding assays, screening inhibitors and selectivity profiling.

SDS-PAGE

Epigenetics; Bromodomains; Bromodomain Proteins (New category)Epigenetics; Others; Recombinant ProteinsProteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & EnzymesProteins and Enzymes; Proteins and Enzymes (A-Z)

BrdT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence. The bromodomain is found in proteins that regulate transcription. BrdT drives a meiotic and post-meiotic gene expression program. It also controls the genome-wide post-meiotic genome reorganization that occurs after histone hyperacetylation in elongating spermatids. It may play a role in the transcriptional regulation of spermatogenesis. It also seems to have a structural ATP-independent role in the reorganization of acetylated chromatin. MyBioSource's recombinant protein includes Bromo 1 domain (22-138 aa) with N-terminal His-tag.

729042272

NP_001229734.2

NM_001242805.2

Q58F21

13.9 kDa (117aa, 22-138 +NT-His Tag)

BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

BRDT: an atypical protein kinase of the BRD family. Possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. A testis-specific protein that is also expressed at a high level in non-small cell lung cancer. Protein type: Protein kinase, atypical; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Cancer Testis Antigen (CTA); ATYPICAL group; BRD family. Chromosomal Location of Human Ortholog: 1p22.1. Cellular Component: nucleus. Molecular Function: histone binding; transcription coactivator activity. Biological Process: chromatin remodeling; male meiosis I; transcription, DNA-dependent; regulation of RNA splicing; RNA splicing; spermatogenesis; male meiosis; cell differentiation; mRNA processing; positive regulation of transcription, meiotic

0.02 mg

200 USD

0.1 mg

480

1 mg

3065