protein

Wnt-2, human recombinant

MBS844978

0.01 mg

345 USD

Recombinant Protein

Wnt-2, human recombinant

[Wnt-2]

[INT1L1; IRP; Int-1-like protein 1; Int-1-related protein]

[protein Wnt-2; Protein Wnt-2; protein Wnt-2; wingless-type MMTV integration site family member 2; Int-1-like protein 1; Int-1-related protein; IRP]

[WNT2]

[WNT2; WNT2; IRP; INT1L1; INT1L1; IRP; IRP]

WNT2_HUMAN

E Coli

360

>=90% by SDS-PAGE and RP-HPLC.

Lyophilized without additives

The lyophilized protein is best-stored desiccated at -20°C. Reconsituted human Wnt-2 should be stored in aliquots at -20°C. Avoid freeze/thaw cycles.

SDS-PAGE

Testing Data

Reconstitution: Centrifuge the vial prior to opening. Reconstitute in sterile ddH 2 O to a concentration >=100 ug/ml. This solution can then be diluted into other aqueous buffers.

Solubility/Reconstitution Instructions: Reconstitute in sterile ddH2O to a concentration >= 100 ug/ml.

Diabetes, Obesity & Metabolic Syndrome; Signaling Pathways in Diabetes and Obesity; GSK-3/Wnt Signaling; Proteins/EnzymesProteins and Enzymes; Proteins and Enzymes (A-Z)Proteins and Enzymes; Other Proteins & EnzymesProteins and Enzymes; Animal-Free Origin

Background: This protein belongs to the Wnt family of proteins. The WNT gene family consists of structurally related genes that encode secreted signaling proteins involved in the Wnt signaling pathway. Wnt gene family members, including Wnt-1 through Wnt-10, play a key role in regulating cellular growth and differentiation. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Wnt-2 is expressed in brain in the thalamus, in fetal and adult lung and in the placenta.

4507927

NP_003382.1

NM_003391.2

P09544

39.9 kDa

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

WNT2: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family. Protein type: Secreted; Extracellular matrix; Cell adhesion; Cell development/differentiation; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 7q31.2. Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; cytoplasm; plasma membrane; extracellular region. Molecular Function: protein binding; frizzled binding; cytokine activity; receptor agonist activity. Biological Process: lens development in camera-type eye; cell fate commitment; Wnt receptor signaling pathway; atrial cardiac muscle morphogenesis; Wnt receptor signaling pathway through beta-catenin; neuron differentiation; positive regulation of fibroblast proliferation; cell-cell signaling; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of cardiac muscle cell proliferation; lung development

0.01 mg

345 USD

0.05 mg

1060

1 mg

7070