protein

Human CellExp CSF1R / CD115 / CD6, human recombinant

MBS844688

0.02 mg

230 USD

Recombinant Protein

Human CellExp CSF1R / CD115 / CD6, human recombinant

[CSF1R/CD115/CD6]

[CD6; CD-6; Cluster of Differentiation 6; FLJ44171; TP120]

[macrophage colony-stimulating factor 1 receptor; Macrophage colony-stimulating factor 1 receptor; macrophage colony-stimulating factor 1 receptor; colony stimulating factor 1 receptor; CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115]

[CSF1R]

[CSF1R; CSF1R; FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R; FMS; CSF-1-R; CSF-1R; M-CSF-R]

CSF1R_HUMAN

HEK 293 cells (lle 20 - Glu 512)

972

> 96% by SDS-PAGE gel

Lyophilized from 0.22 um filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

Store at -20°C. After reconstitution, aliquot and store at -20°C or -70°C for up to 3 months. Avoid repeated freezing and thawing cycles. No activity loss was observed after storage in lyophilized state for 1 year (4°C) and after reconstitution under sterile conditions for 3 months (-70°C).

SDS-PAGE

Reconstitution: Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex. Endotoxin Level: 50 for this effect is typically 1.5-8.7 pg/ml in the presence of 1 ng/ml of rhMCSF.

Cytokines, Growth Factors & Hormones; Human cell expressed recombinant proteins Proteins and Enzymes; Human cell expressed recombinant proteins Cytokines, Growth Factors & Hormones; CDsProteins and Enzymes; Cytokines, Growth Factors & Hormones; CDsCytokin

Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the type III subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation. Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

569026720

NP_001275634.1

NM_001288705.1

P07333

This protein rhCSF1R is fused with a C-terminal 6×his tag and has a calculated MW of 55.1 kDa. The predicted N-terminus is Ile 20. DTT-reduced protein migrates as 80-95 kDa polypeptide in SDS-PAGE.

C-MYB Transcription Factor Network Pathway (138073); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Integrins In Angiogenesis Pathway (137999); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096)

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

CSFR: an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors. Protein type: Oncoprotein; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; TK group; PDGFR family. Chromosomal Location of Human Ortholog: 5q32. Cellular Component: cell surface; integral to plasma membrane; plasma membrane; receptor complex. Molecular Function: macrophage colony stimulating factor receptor activity; protein homodimerization activity; cytokine binding; protein phosphatase binding; ATP binding. Biological Process: regulation of bone resorption; macrophage differentiation; phosphoinositide-mediated signaling; peptidyl-tyrosine phosphorylation; monocyte differentiation; protein amino acid autophosphorylation; multicellular organismal development; cytokine and chemokine mediated signaling pathway; osteoclast differentiation; signal transduction; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell shape; cell proliferation; positive regulation of cell proliferation; ruffle organization and biogenesis; innate immune response; hemopoiesis; phosphatidylinositol metabolic process; positive regulation of protein amino acid phosphorylation; inflammatory response; intercellular junction maintenance; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration. Disease: Leukoencephalopathy, Diffuse Hereditary, With Spheroids

0.02 mg

230 USD

0.1 mg

675