protein

MAGE-1, human recombinant

MBS844638

0.005 mg

655 USD

Recombinant Protein

MAGE-1, human recombinant

[MAGE-1]

[Melanoma-associated antigen 1; MAGE-1 antigen; Antigen MZ2-E; Cancer/testis antigen 1,1; CT1,1; MAGEA1; MAGE1; MAGE1A; MGC9326;]

[melanoma-associated antigen 1; Melanoma-associated antigen 1; melanoma-associated antigen 1; melanoma antigen family A1; Antigen MZ2-E; Cancer/testis antigen 1.1; CT1.1; MAGE-1 antigen]

[MAGEA1]

[MAGEA1; MAGEA1; CT1.1; MAGE1; MAGE1; MAGE1A; CT1.1]

MAGA1_HUMAN

E Coli

309

>=90%

Liquid form. 50 uL (100 ug/mL)purified human MAGE-1- in 50 mM Tris- Acetate, pH 7.5, 1mM EDTA and 20% glycerol.

Stored at 4°C for 2-7 days. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) and store aliquots at -20°C or -70°C . Avoid freeze-thaw cycles.

ELISA, Inhibition Assays, Western Blotting.

Handling: Centrifuge the vial prior to opening.

Background: Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

148276977

NP_004979.3

NM_004988.4

P43355

38 kDa

Delta-Notch Signaling Pathway (198879)

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

MAGE-A1: a tumor antigen expressed in a variety of tumor cells and in the testis. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Protein type: Cell surface. Chromosomal Location of Human Ortholog: Xq28. Cellular Component: cytoplasm; plasma membrane; nucleus. Molecular Function: protein binding; histone deacetylase binding. Biological Process: transcription, DNA-dependent; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter

0.005 mg

655 USD