Human CellExp FCER1A / FCE1A, human recombinant | MyBioSource MBS844143 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human CellExp FCER1A / FCE1A, human recombinant

catalog :

MBS844143

quantity :

0.01 mg

price :

230 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS844143

products type :

Recombinant Protein

products full name :

Human CellExp FCER1A / FCE1A, human recombinant

products short name :

[FCER1A/FCE1A]

products name syn :

[FCER1A; FCE1A; Ferris]

other names :

[high affinity immunoglobulin epsilon receptor subunit alpha; High affinity immunoglobulin epsilon receptor subunit alpha; high affinity immunoglobulin epsilon receptor subunit alpha; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha]

products gene name :

[FCER1A]

other gene names :

[FCER1A; FCER1A; FCE1A; FcERI; FCE1A; FcERI]

uniprot entry name :

FCERA_HUMAN

host :

HEK293 cells (Val 26 - Gln 205)

sequence length :

257

purity :

>=90% by SDS-PAGE gel

form :

Lyophilized from 0.22 mum filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization. Appearance: Lyophilized

storage stability :

Store at -20 degree C. After reconstitution , aliquot and store at -20 degree C and use within 3 months. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

image1 heading :

Testing Data

other info2 :

Solubility/Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C. Endotoxin Level: <1 EU/mug by LAL method. Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized human FCER1A at 2 mug/ml (100 mul/well). The concentration of Human IgE that produces 50% of the optimal binding response is found to be approximately 0.1 - 0.4 ug/ml. Results: Measured by its binding ability in a functional ELISA. Immobilized human FCER1A at 2 mug/ml (100 mul/well). The concentration of Human IgE that produces 50% of the optimal binding response is found to be approximately 0.1 - 0.4 ug/ml. Handling: Centrifuge the vial prior to opening.

products categories :

Proteins and Enzymes; Human cell expressed recombinant proteinsProteins and Enzymes; Proteins and Enzymes (A-Z)Proteins and Enzymes; Other Proteins & Enzymes

products description :

Background: High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) is also known as Fc-epsilon RI-alpha (FcERI), IgE Fc receptor subunit alpha, FCE1A. FCER1A contains two Ig-like (immunoglobulin-like) domains. FCER1A binds to the Fc region of immunoglobulins epsilon and is a high affinity receptor. FCER1A is responsible for initiating the allergic response, which binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. FCER1A plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.

ncbi gi num :

4503675

ncbi acc num :

NP_001992.1

ncbi gb acc num :

NM_002001.3

uniprot acc num :

P12319

ncbi mol weight :

This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 21.9 kDa. The predicted N-terminus is Val 26. DTT-reduced Protein migrates as 40-60 kDa due to glycosylation.

ncbi pathways :

Asthma Pathway (83120); Asthma Pathway (532); Fc Epsilon RI Signaling Pathway (83082); Fc Epsilon RI Signaling Pathway (493); Fc Epsilon Receptor (FCERI) Signaling Pathway (1269298); Fc-epsilon Receptor I Signaling In Mast Cells Pathway (138050); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Sphingolipid Signaling Pathway (1144995); Sphingolipid Signaling Pathway (1158200)

ncbi summary :

The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

uniprot summary :

Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

size1 :

0.01 mg

price1 :

230 USD

size2 :

0.05 mg

price2 :

655

more info or order :

MyBioSource product webpage