product summary
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company name :
MyBioSource
product type :
protein
product name :
Proteinase 3 (PR3), Human Neutrophil
catalog :
MBS844097
quantity :
0.025 mg
price :
350 USD
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS844097 image 1
product information
catalog number :
MBS844097
products type :
Protein
products full name :
Proteinase 3 (PR3), Human Neutrophil
products short name :
[Proteinase 3 (PR3)]
products name syn :
[AGP7; C-ANCA antigen; Leukocyte proteinase 3; Neutrophil proteinase 4; P29; Wegener autoantigen]
other names :
[myeloblastin; Myeloblastin; myeloblastin; proteinase 3; AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen]
products gene name :
[AGP7]
other gene names :
[PRTN3; PRTN3; MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA; MBN; PR-3; PR3; NP-4]
uniprot entry name :
PRTN3_HUMAN
host :
Human Neutrophils
sequence length :
256
purity :
>=95% by SDS-PAGE
form :
Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl
storage stability :
Aliquot and store at - 70°C or lower. Avoid repated freezing and thawing cycles. Shipping: Dry Ice
tested application :
SDS-PAGE
image1 heading :
Testing Data
other info1 :
Host Note: Human Neutrophil. Prepared from whole blood shown to be non reactive for HBsAg, anti HCV, anti HBc, and negative for anti HIV 1 & 2 by FDA approved tests. Extinction Coefficient: 1.00
other info2 :
Handling: Centrifuge the vial prior to opening.
products categories :
Proteins and Enzymes; Native Proteins (NEW CATEGORY)Proteins and Enzymes; Proteases; Other (NEW CATEGORY)Proteins and Enzymes; Proteins and Enzymes (A-Z)
products description :
Background: Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by alpha1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation.
ncbi gi num :
71361688
ncbi acc num :
NP_002768.3
ncbi gb acc num :
NM_002777.3
uniprot acc num :
P24158
ncbi mol weight :
29 kDa
ncbi pathways :
C-MYB Transcription Factor Network Pathway (138073); Common Pathway Of Fibrin Clot Formation (1269371); Formation Of Fibrin Clot (Clotting Cascade) Pathway (1269368); Hemostasis Pathway (1269340)
uniprot summary :
PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily. Protein type: EC 3.4.21.76; Protease; Cell cycle regulation. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: extracellular matrix; extracellular space; plasma membrane; cytosol. Molecular Function: enzyme binding; serine-type peptidase activity; serine-type endopeptidase activity. Biological Process: negative regulation of phagocytosis; collagen catabolic process; positive regulation of cell proliferation; blood coagulation; proteolysis
size1 :
0.025 mg
price1 :
350 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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