Defensins, Alpha, Mixed from Human Neutrophils (HNP, Human Neutrophil Peptides) | MyBioSource MBS844091 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Defensins, Alpha, Mixed from Human Neutrophils (HNP, Human Neutrophil Peptides)

catalog :

MBS844091

quantity :

0.025 mg

price :

305 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS844091

products type :

Protein

products full name :

Defensins, Alpha, Mixed from Human Neutrophils (HNP, Human Neutrophil Peptides)

products short name :

[Defensins, Alpha, Mixed from Human Neutrophils (HNP, Human Neutrophil Peptides)]

products name syn :

[Neutrophil defensin 4; Defensin; alpha 4; HNP-4]

other names :

[neutrophil defensin 4 preproprotein; Neutrophil defensin 4; neutrophil defensin 4; defensin, alpha 4, corticostatin; Defensin, alpha 4; HNP-4; HP-4]

products gene name :

[HNP-4]

other gene names :

[DEFA4; DEFA4; HP4; DEF4; HP-4; HNP-4; DEF4; HP-4]

uniprot entry name :

DEF4_HUMAN

host :

Human Neutrophil

sequence length :

purity :

>=95% by SDS-PAGE.

form :

Frozen in 1 M acetic acid.

storage stability :

Aliquot and store at -70°C or lower. Avoid repeated freezing and thawing cycles. Ships in blue ice.

tested application :

SDS-PAGE

image1 heading :

Testing Data

other info1 :

Extinction coefficient: 2.95 kDa. Host Note: Prepared from whole blood shown to be non-reactive for HBsAg, anti- HCV , anti HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

other info2 :

Handling: Centrifuge the vial prior to opening.

products categories :

Proteins and Enzymes; Native Proteins (NEW CATEGORY)Proteins and Enzymes; Proteins and Enzymes (A-Z)

products description :

Background: Alpha defensins are a family of mammalian defensin peptides. In general, defensins are small cysteine-rich cationic proteins found in both vertebrates and invertebrates. These mixed alpha defensins are purified from human neutrophils. These peptides are active in killing bacteria, fungi, and enveloped viruses, and therefore, enable the neutrophils to inactivate and destroy potential pathogens. Defensins damage or kill ingested microbes by penetrating the microbial' s cell membrane by way of electrical attraction, and consequently forming pores in the membrane. Human neutrophil-derived alpha-defensins (HNPs) are capable of enhancing phagocytosis by mouse macrophages. HNP1-3 have been reported to increase the production of tumor necrosis factor (TNF) and IL-1, while decreasing the production of IL-10 by monocytes. Increased levels of proinflammatory factors (e.g., IL-1, TNF, histamine and prostaglandin D2) and suppressed levels of IL-10 at the site of microbial infection are likely to amplify local inflammatory responses. This might be further reinforced by the capacity of some human and rabbit alpha-defensins to inhibit the production of immunosuppressive glucocorticoids by competing for the binding of adrenocorticotropic hormone to its receptor. Moreover, human alpha-defensins can enhance or suppress the activation of the classical pathway of complement in vitro by binding to solid-phase or fluid-phase complement C1q, respectively. The capacity of defensins to enhance phagocytosis, promote neutrophil recruitment, enhance the production of proinflammatory cytokines, suppress anti-inflammatory mediators and regulate complement activation argues that defensins upregulate innate host inflammatory defenses against microbial invasion.

ncbi gi num :

4503303

ncbi acc num :

NP_001916.1

ncbi gb acc num :

NM_001925.2

uniprot acc num :

P12838

ncbi mol weight :

< 3.5 kDa

ncbi summary :

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014]

uniprot summary :

DEFA4: Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production. Belongs to the alpha-defensin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 8p23. Cellular Component: extracellular space; Golgi lumen; extracellular region. Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus

size1 :

0.025 mg

price1 :

305 USD

more info or order :

MyBioSource product webpage