Alpha 2 Macroglobulin, Human Plasma | MyBioSource MBS844090 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Alpha 2 Macroglobulin, Human Plasma

catalog :

MBS844090

quantity :

1 mg

price :

180 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS844090

products type :

Protein

products full name :

Alpha 2 Macroglobulin, Human Plasma

products short name :

[Alpha 2 Macroglobulin]

products name syn :

[C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2M; CPAMD5; FWP007]

other names :

[alpha-2-macroglobulin; Alpha-2-macroglobulin; alpha-2-macroglobulin; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5]

products gene name :

[A2M]

other gene names :

[A2M; A2M; A2MD; CPAMD5; FWP007; S863-7; CPAMD5; Alpha-2-M]

uniprot entry name :

A2MG_HUMAN

sequence length :

1474

purity :

>=95% by SDS-PAGE

form :

Lyophilized from 30 mM Na Phosphate, pH 7.0, with glycine as a stabilizer. Appearance: Lyophilized

storage stability :

At -20 degree C or lower. Shelf Life: 12 months

tested application :

SDS-PAGE

image1 heading :

Testing Data

other info1 :

Source: Human Plasma. Shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV1&2 by FDA approved tests. Extinction Coefficient: 0.81

other info2 :

Solubility/Reconstitution Instructions: In water or aqueous buffer. Handling: Centrifuge the vial prior to opening.

products categories :

Proteins and Enzymes; Native Proteins (NEW CATEGORY)Proteins and Enzymes; Proteins and Enzymes (A-Z)

products description :

Background: Alpha 2 macroglobulin (A2M) is a major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. It functions as a broad-spectrum protease-binding protein. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. It is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to alpha 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer's disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M also binds soluble beta-amyloid, of which it mediates degradation. Protease-conjugated alpha2-macroglobulin is selectively bound by cells contacting the body fluids and alpha2-macroglobulin and its protease cargo are then internalized and degraded in secondary lysosomes of those cells. In addition to this function as an agent for protease clearance, Alpha2-macroglobulin binds a variety of other ligands, including several peptide growth factors and modulates the activity of a lectin-dependent cytolytic pathway in arthropods. Multifunctional, it promotes growth of mammalian cells in culture, stimulates the regeneration of lymphocytes in irradiated mice, possesses a transport function for zinc and is a proteinase inhibitor that controls the clotting and fibrinolytic system. Clinically levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases.

ncbi gi num :

66932947

ncbi acc num :

NP_000005.2

ncbi gb acc num :

NM_000014.4

uniprot acc num :

P01023

ncbi mol weight :

725 kDa (Homotetramer, Subunit size: 180 kDa)

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Degradation Of The Extracellular Matrix Pathway (1270257); Extracellular Matrix Organization Pathway (1270244); Formation Of Fibrin Clot (Clotting Cascade) Pathway (1269368); HDL-mediated Lipid Transport Pathway (1270007); Hemostasis Pathway (1269340); IL6-mediated Signaling Events Pathway (137932); Intrinsic Pathway Of Fibrin Clot Formation (1269370)

ncbi summary :

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]

uniprot summary :

A2M: Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. Protein type: Secreted; Inhibitor; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 12p13.31. Cellular Component: extracellular region; cytosol. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding. Biological Process: negative regulation of complement activation, lectin pathway; extracellular matrix disassembly; platelet activation; regulation of small GTPase mediated signal transduction; extracellular matrix organization and biogenesis; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway. Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency

size1 :

1 mg

price1 :

180 USD

more info or order :

MyBioSource product webpage