protein

Bacterial / Permeability-Increasing Protein, Human Neutrophil (BPI, CAP57)

MBS844054

0.05 mg

255 USD

Protein

Bacterial / Permeability-Increasing Protein, Human Neutrophil (BPI, CAP57)

[Bacterial/Permeability-Increasing Protein]

[BPI; CAP57]

[bactericidal permeability-increasing protein; Bactericidal permeability-increasing protein; bactericidal permeability-increasing protein; bactericidal/permeability-increasing protein; CAP 57]

[BPI]

[BPI; BPI; rBPI; BPIFD1; BPI]

BPI_HUMAN

Human Neutrophil

487

>=95% by SDS-PAGE

Frozen in 80 mM Citrate Phosphate, pH 5.6, 0.75 M NaCl.

Aliquot and store at -70°C or lower. Avoid repeated freezing and thawing cycles. Shipping: Dry Ice.

SDS-PAGE

Testing Data

Source: Human Whole Blood. Shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. Extinction Coefficient: 1.00. Appearance: Frozen

Handling: Centrifuge the vial prior to opening.

Proteins and Enzymes; Native Proteins (NEW CATEGORY)Proteins and Enzymes; Proteins and Enzymes (A-Z)

Background: Bactericidal/permeability increasing protein (BPI) is a 456 residue protein which is part of the innate immune system. BPI was initially identified in neutrophils, but is found in other tissues including the epithelial lining of mucus membranes. It is an endogenous antibiotic protein with potent killing activity against Gram-negative bacteria. It binds to compounds called lipopolysaccharides produced by Gram-negative bacteria. Lipolysaccharides are potent activators of the immune system; however BPI at certain concentrations can prevent this activation. Bacterial/Permeability-Increasing Protein (BPI) is present in the azurophilic granules of polymorphonuclear leukocytes (PMN). BPI is toxic only toward Gram-negative bacteria. This specificity is attributable to the strong attraction of BPI for the lipopolysaccharides (LPS) in the bacterial envelope. BPI is also an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis.

157276599

NP_001716.2

NM_001725.2

P17213

55 kDa

This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]

BPI: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. Protein type: Secreted, signal peptide; Secreted; Cell surface. Chromosomal Location of Human Ortholog: 20q11.23. Cellular Component: integral to plasma membrane; cytoplasm. Molecular Function: lipopolysaccharide binding. Biological Process: negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; immune response; negative regulation of tumor necrosis factor production; negative regulation of macrophage activation; defense response to Gram-negative bacterium

0.05 mg

255 USD

0.1 mg

430