protein

Hemopexin, Human Plasma

MBS844050

1 mg

510 USD

Protein

Hemopexin, Human Plasma

[Hemopexin]

[Beta-1B-glycoprotein; HPX]

[hemopexin; Hemopexin; hemopexin; hemopexin; Beta-1B-glycoprotein]

[HPX]

[HPX; HPX; HX]

HEMO_HUMAN

462

>=95% by SDS-page

Lyophilized. Lyophilized from 11.9 mM phosphate, 137 mM NaCl, 2.7 mM KCl, pH 7.4

Store at -20°C or lower. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Testing Data

Source: Human Plasma. Prepared from plasma shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1&2 by FDA approved tests. Extinction coefficient: 1.97

Handling: Centrifuge the vial prior to opening.

Proteins and Enzymes; Native Proteins Proteins and Enzymes; Proteins and Enzymes (A-Z)Proteins and Enzymes; Other Proteins & EnzymesCell Damage & Oxidative Stress; Enzymes

Background: Hemopexin is a single-chain protein belonging to the family of blood transport proteins. It binds to heme released into the bloodstream during the degradation process. Recent studies have demonstrated that hemopexin acts as an extracellular antioxidant against hemoglobin-mediated damage in inflammation. Hemopexin protects against heme toxicity and conserves and recycles iron. Abnormal levels of hemopexin are associated with hemolytic anemia, chronic neuromuscular disease, and acute intermittent porphyria.

11321561

NP_000604.1

NM_000613.2

P02790

57.0 kDa

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1269897); Scavenging Of Heme From Plasma Pathway (1269898); Vesicle-mediated Transport Pathway (1269876)

This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]

HPX: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. Belongs to the hemopexin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 11p15.5-p15.4. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; metal ion binding; heme transporter activity. Biological Process: positive regulation of humoral immune response mediated by circulating immunoglobulin; receptor-mediated endocytosis; heme transport; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of immunoglobulin production; viral reproduction; hemoglobin metabolic process; cellular iron ion homeostasis; heme metabolic process

1 mg

510 USD