protein

Lipoprotein a [Lp(a)], Human Plasma

MBS844012

0.05 mg

210 USD

Protein

Lipoprotein a [Lp(a)], Human Plasma

[Lipoprotein a [Lp(a)]]

[Lpa; Lipoprotein a]

[Apolipoprotein(a); Apolipoprotein(a); apolipoprotein(a); lipoprotein, Lp(a)]

[LPA]

[LPA; LPA; LP; AK38; APOA; Apo(a); Lp(a)]

APOA_HUMAN

Human Plasma

4548

Essentially free of other plasma lipoproteins as determined by electrophoresis using Fat Red 7B staining for lipids and Coomassie Blue for proteins. Greater than 95% of total lipoprotein content by electrophoresis.(>=95% by SDSPAGE).

Liquid in PBS with 0.05% NaN3

2 to 4°C. Do not freeze!

SDS-PAGE; HPLC

SDS-PAGE

Purity: Essentially free of other plasma lipoproteins as determined by electrophoresis using Fat Red 7B staining for lipids and Coomassie Blue for proteins. Greater than 95% of total lipoprotein content by electrophoresis. Host Note: Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti HBc, and negative for anti-HIV 1&2 by FDA approved tests. Density: 1.063-1.1g/ml; Composition: 65% lipid, 27% protein, 8% carbohydrate

Handling: Centrifuge the vial prior to opening.

Proteins and Enzymes; LipoproteinsProteins and Enzymes; Native ProteinsProteins and Enzymes; Proteins and Enzymes (A-Z)

In a normal fasting individual, Lp(a) concentrations range from 20-760 mg/L. Lp(a) levels are associated with premature atherosclerosis; thus elevated Lp(a) is considered a high risk factor for coronary heart disease.

114062

P08519.1

P08519

280,000-700,000

LDL-mediated Lipid Transport Pathway (1270008); Lipid Digestion, Mobilization, And Transport Pathway (1270002); Lipoprotein Metabolism Pathway (1270005); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Amb2 Integrin Signaling Pathway (137945)

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]

LPA: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. Belongs to the peptidase S1 family. Plasminogen subfamily. Protein type: Inhibitor; Protease; EC 3.4.21.-. Chromosomal Location of Human Ortholog: 6q26. Cellular Component: extracellular region. Molecular Function: heparin binding; protein binding; serine-type endopeptidase activity; fibronectin binding; endopeptidase inhibitor activity; apolipoprotein binding. Biological Process: receptor-mediated endocytosis; blood circulation; lipoprotein metabolic process; lipid metabolic process; lipid transport; proteolysis

0.05 mg

210 USD