ATGL Antibody | MyBioSource MBS841172 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ATGL Antibody

catalog :

MBS841172

quantity :

0.03 mg

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS841172

products type :

Antibody

products full name :

ATGL Antibody

products short name :

[ATGL]

products name syn :

[Adipose Triglyceride Lipase; Patatin-like phospholipase domain-containing protein 2; Desnutrin; Transport-secretion protein 2; TTS2]

other names :

[adipose triglyceride lipase; Patatin-like phospholipase domain-containing protein 2; patatin-like phospholipase domain-containing protein 2; patatin-like phospholipase domain containing 2; Adipose triglyceride lipase; Calcium-independent phospholipase A2; Desnutrin; IPLA2-zeta; Pigment epithelium-derived factor; TTS2.2; Transport-secretion protein 2; TTS2]

products gene name :

[ATGL]

other gene names :

[PNPLA2; PNPLA2; ATGL; TTS2; PEDF-R; FP17548; TTS-2.2; iPLA2zeta; 1110001C14Rik; ATGL; TTS2]

uniprot entry name :

PLPL2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

504

purity :

Affinity purified

form :

100 ug (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. Appearance: Colorless liquid

concentration :

0.5 mg/ml

storage stability :

At -20 degree C for short term. For long term storage, aliquot and freeze at -70 degree C. Avoid repeated freeze/defrost cycles. Shelf Life: 12 months

tested application :

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

app notes :

Western blotting (0.5-4 ug/ml), Immunohistochemistry (5 ug/ml), and immunoprecipitation. recognizes 54 kDa ATGL in samples from human, mouse and rat origins. However, the optimal concentrations should be determined individually.

image1 heading :

Testing Data

other info1 :

Immunogen: Synthetic peptide corresponding to residues surrounding amino acids 385 of human ATGL. Positive Control: Western Blot: rat kidney tissue lysate. IHC: Heart tissue

other info2 :

Handling: The antibody solution should be gently mixed before use.

products description :

Background: Triglycerides form an important energy store in many living organisms. Adipose tissue serves as the primary storage depot for triglycerides in mammals. Lipolytic enzymes mobilize triglycerides during periods of starvation to provide organisms with necessary energy. Hormone-sensitive lipase (HSL), the first identified lipolytic enzyme, hydrolyzes triglycerides in mammalian adipose tissues. Additional lipolytic enzymes, including adipose triglyceride lipase (ATGL), have also been discovered. The primary function of ATGL is to catalyze the hydrolysis of the first ester bond of lipid molecules. This enzyme may provide diglyceride substrates for HSL hydrolysis. ATGL is abundantly expressed in murine white and brown adipose tissue, and is highly substrate specific. ATGL was independently identified as desnutrin and the TG-hydrolace inducible phospholipase-A2-z.

ncbi gi num :

58759051

ncbi acc num :

AAW81962

ncbi mol weight :

19,875 Da

ncbi pathways :

Acyl Chain Remodeling Of DAG And TAG Pathway (1270056); Acylglycerol Degradation Pathway (413388); Acylglycerol Degradation Pathway (468272); Fatty Acid Beta Oxidation Pathway (198865); Glycerolipid Metabolism Pathway (82986); Glycerolipid Metabolism Pathway (361); Glycerophospholipid Biosynthesis Pathway (1270054); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001)

ncbi summary :

This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010]

uniprot summary :

PNPLA2: the rate-limiting lipolytic enzyme in mammals, flies, and yeast. Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Upregulated by exercise training in human skeletal muscle. Has acylglycerol transacylase activity. May act coordinately with HSL within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Interacting with ABHD5 stimulates its triglyceride hydrolase activity. Despite a colocalization in lipid droplets, it probably does not interact with perilipin. Transcriptionally regulated by FOXO1A. Defects cause neutral lipid storage disease (NLSD), an autosomal recessive disorder characterized by the excessive accumulation of neutral lipids in multiple tissues. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; EC 3.1.1.3; Lipase. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; plasma membrane; integral to membrane; lipid particle; cytosol. Molecular Function: triacylglycerol lipase activity. Biological Process: sequestering of lipid; phospholipid metabolic process; glycerophospholipid biosynthetic process; triacylglycerol catabolic process. Disease: Neutral Lipid Storage Disease With Myopathy

size1 :

0.03 mg

price1 :

150 USD

size2 :

0.1 mg

price2 :

290

more info or order :

MyBioSource product webpage