product summary
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company name :
MyBioSource
product type :
antibody
product name :
PDE3B Antibody
catalog :
MBS840862
quantity :
0.2 mg
price :
290 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
product information
catalog number :
MBS840862
products type :
Antibody
products full name :
PDE3B Antibody
products short name :
PDE3B
products name syn :
PDE3B; phosphodiesterase type-3
other names :
PDE3B protein; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; phosphodiesterase 3B, cGMP-inhibited; CGIPDE1; CGIP1; Cyclic GMP-inhibited phosphodiesterase B; CGI-PDE B
products gene name :
PDE3B
other gene names :
PDE3B; PDE3B; HcGIP1; cGIPDE1; CGIP1; CGI-PDE B
uniprot entry name :
PDE3B_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
1061
purity :
Affinity purified
form :
200 ug (0.5 mg/ml) affinity purified rabbit anti-PDE3B polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal. Appearance: Colorless liquid
storage stability :
At -20 degree C for long term storage. Aliquot and freeze at -70 degree C. Avoid repeated freeze/thaw cycles
tested application :
Western Blot (WB)
app notes :
The antibody can be used for Western blotting (1-4 ug/ml). However, the optimal conditions should be determined individually, Blocking peptide (Catalod Number: MBS843957 is available separately.
other info1 :
Immunogen: Synthetic peptide surrounding amino acid 948 of mouse PDE3B. Positive Control: Jurkat, Rat kidney, 3T3 cell lysates
other info2 :
Handling: The antibody solution should be gently mixed before use.
products categories :
Antibodies & Supporting Tools; Primary Antibodies (A-Z)
products description :
Background: The phosphodiesterase type-3 (PDE3) family is comprised of 2 isoforms, PDE3A and PDE3B.Phosphodiesterases (PDE) are crucial in the regulation of the intracellular level of the second messenger cAMP by hydrolyzing cAMP to 5'AMP. PDE3B has two splice variants that are expressed in adipocyte tissue, hepatocyte, kidney, spermatocytes and embryonic neuroepithelium. Both PDE3A and PDE3B are potential targets for the treatment of obesity.
ncbi gi num :
219519624
ncbi acc num :
AAI44249.1
ncbi mol weight :
118,809 Da
uniprot summary :
PDE3B: a cGMP-inhibited phosphodiesterase 1 involved in fat metabolism. Inhibition of PDE3B can augment PDE4 inhibitor-induced apoptosis in some patients with chronic lymphocytic leukemia. Protein type: Membrane protein, integral; Nucleotide Metabolism - purine; Membrane protein, multi-pass; EC 3.1.4.17; Phosphodiesterase. Chromosomal Location of Human Ortholog: 11p15.1. Cellular Component: Golgi apparatus; membrane; endoplasmic reticulum; integral to membrane; cytosol. Molecular Function: protein kinase B binding; protein binding; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; metal ion binding; 3 ,5 -cyclic-nucleotide phosphodiesterase activity. Biological Process: negative regulation of angiogenesis; cellular response to insulin stimulus; negative regulation of lipid catabolic process; cAMP catabolic process; insulin receptor signaling pathway; negative regulation of cell adhesion; angiogenesis; blood coagulation; glucose homeostasis; regulation of insulin secretion; negative regulation of cell adhesion mediated by integrin; endocrine pancreas development
size1 :
0.2 mg
price1 :
290 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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