BAFFR antibody | MyBioSource MBS838926 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

BAFFR antibody

catalog :

MBS838926

quantity :

0.1 mg

price :

430 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of BAFF-R expression in rat kidney tissue lysate.

product information

catalog number :

MBS838926

products type :

Antibody

products full name :

BAFFR antibody

products short name :

[BAFFR]

products name syn :

[Polyclonal BAFFR; anti-BAFFR; MGC138235; CD268; BAFF-R; TNFRSF13C]

other names :

[BAFF receptor; Tumor necrosis factor receptor superfamily member 13C; tumor necrosis factor receptor superfamily member 13C; tumor necrosis factor receptor superfamily, member 13C; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD_antigen: CD268]

products gene name :

[BAFFR]

other gene names :

[TNFRSF13C; TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin; BAFFR; BR3; BAFF-R]

uniprot entry name :

TR13C_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

184

purity :

BAFFR antibody was purified by affinity chromatography

form :

Affinity purified liquid in PBS, pH7.2, with 30% Glycerol, 0.5% BSA, and 0.1% Thimersal.

concentration :

0.5 mg/ml

storage stability :

Shipping with blue ice. Upon receipt store at -20 degree C. For long term storage, aliquot and freeze at -70 degree C. Avoid repeat freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB: 0.5-4 ug/ml. IHC: 5ug/ml

image1 heading :

Western Blot (WB)

other info1 :

Biological Significance: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-Jun N-terminal kinase.

other info2 :

Immunogen: Synthetic peptide surrounding amino acid 159 of mouse BAFF-R.

products categories :

Cytokines & Growth Factors; Purified Polyclonal Antibodies

products description :

Rabbit polyclonal BAFFR antibody

ncbi gi num :

85567349

ncbi acc num :

AAI12031.1

ncbi mol weight :

18,935 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); NF-kappa B Signaling Pathway (634527); Primary Immunodeficiency Pathway (83125); Primary Immunodeficiency Pathway (537)

ncbi summary :

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

uniprot summary :

BAFF-R: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4); also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Receptor, misc.; Cell cycle regulation; Membrane protein, integral. Chromosomal Location of Human Ortholog: 22q13.1-q13.31. Cellular Component: integral to membrane; external side of plasma membrane. Biological Process: B cell costimulation; B cell homeostasis; T cell costimulation; positive regulation of germinal center formation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process. Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 4

size1 :

0.1 mg

price1 :

430 USD

more info or order :

MyBioSource product webpage