IGFBP3 antibody | MyBioSource MBS838129 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IGFBP3 antibody

catalog :

MBS838129

quantity :

0.5 mg

price :

815 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[M83147]

reactivity :

human

application :

ELISA, radioimmunoassay, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS838129

products type :

Antibody

products full name :

IGFBP3 antibody

products short name :

[IGFBP3]

products name syn :

[Monoclonal IGFBP3; Anti-IGFBP3; growth hormone-dependent binding protein; IBP-3; IBP3; IGF-binding protein 3; IGFBP-3; IGFBP3; insulin-like growth factor binding protein 3; Insulin-like growth factor-binding protein 3; acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP-53]

other names :

[insulin-like growth factor-binding protein 3 isoform a; Insulin-like growth factor-binding protein 3; insulin-like growth factor-binding protein 3; insulin-like growth factor binding protein 3]

products gene name :

[IGFBP3]

other gene names :

[IGFBP3; IGFBP3; IBP3; BP-53; IBP3; IBP-3; IGF-binding protein 3; IGFBP-3]

uniprot entry name :

IBP3_HUMAN

clonality :

Monoclonal

isotype :

IgG1 kappa

clone :

[M83147]

host :

Mouse

sequence length :

297

specificity :

Recognizes natural and recombinant Human IGFBP3

purity :

IGFBP3 antibody was purified by urified by Protein A affinity chromatography

form :

Liquid in 0.1 BBS,pH 8.0, with no preservatives.

concentration :

3.12 mg/mL

storage stability :

Store at 4°C

tested application :

ELISA (EIA), Radioimmunoassay (RIA), Lateral Flow

app notes :

MBS838129 can be used as the detection antibody in a matched pair immunoassay inconjunction with MBS838032 as the capture antibody

other info2 :

Immunogen: Human recombinant IGFBP-3 . Biological Significance: IGF- binding proteins such as IGFBP33 prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.

products categories :

Cytokines & Growth Factors

products description :

Mouse Monoclonal IGFBP3 antibody

ncbi gi num :

62243248

ncbi acc num :

NP_001013416.1

ncbi gb acc num :

NM_001013398.1

ncbi pathways :

Direct P53 Effectors Pathway (137939); Integrated Pancreatic Cancer Pathway (711360); Metabolism Of Proteins Pathway (106230); Myometrial Relaxation And Contraction Pathways (198759); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908); Senescence And Autophagy Pathway (198780); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987); P53 Signaling Pathway (83055); P53 Signaling Pathway (465)

ncbi summary :

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

uniprot summary :

IGFBP3: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Protein type: Secreted, signal peptide; Cell development/differentiation; Secreted. Chromosomal Location of Human Ortholog: 7p12.3. Cellular Component: insulin-like growth factor binding protein complex; extracellular space; extracellular region; nucleus. Molecular Function: insulin-like growth factor binding; protein binding; insulin-like growth factor I binding; fibronectin binding; metal ion binding; insulin-like growth factor II binding; protein tyrosine phosphatase activator activity. Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of catalytic activity; regulation of insulin-like growth factor receptor signaling pathway; positive regulation of apoptosis; negative regulation of smooth muscle cell proliferation; apoptosis; negative regulation of smooth muscle cell migration; protein amino acid phosphorylation; positive regulation of myoblast differentiation; negative regulation of signal transduction; osteoblast differentiation; negative regulation of cell proliferation; cellular protein metabolic process; positive regulation of MAPKKK cascade; negative regulation of protein amino acid phosphorylation; regulation of cell growth

size1 :

0.5 mg

price1 :

815 USD

size2 :

1 mg

price2 :

1575

more info or order :

MyBioSource product webpage