antibody

Renin antibody

MBS838113

0.25 mg

410 USD

monoclonal

mouse

nonconjugated

[M83118]

ELISA, radioimmunoassay, enzyme immunoassay

Antibody

Renin antibody

[Renin]

[Monoclonal Renin; Anti-Renin; angiotensin-forming enzyme; Angiotensinogenase; FLJ10761; HNFJ2; REN; RENI; Renin; renin precursor renal]

[renin preproprotein; Renin; renin; renin; Angiotensinogenase]

[REN; REN; HNFJ2]

RENI_HUMAN

Monoclonal

IgG1 kappa

[M83118]

Mouse

100% for active renin, 10% for prorenin

Recognizes active Renin

Renin antibody was purified by urified by Protein A affinity chromatography

Purified unconjugated liquid in 100mM PBS, pH 7.4, with 0.5g/l sodium azide

1.18 mg/ml

Store at 4°C

ELISA (EIA), Radioimmunoassay (RIA), Lateral Flow

MBS838113 can be used as the detection antibody in a matched pair immunoassay in conjunction with MBS838098 or MBS838707 as the capture antibody.

Immunogen: Human recombinant renin

Proteases, Inhibitors, & Enzymes

Renin is a highly specific endopeptidase, whose only known function is to genterate angiotensin I from antiotensinogen in the plasma initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidneys.

4506475

NP_000528.1

NM_000537.3

ACE Inhibitor Pathway (198763); Metabolism Of Angiotensinogen To Angiotensins Pathway (685555); Metabolism Of Proteins Pathway (106230); Peptide Hormone Metabolism Pathway (771603); Renin-angiotensin System Pathway (83075); Renin-angiotensin System Pathway (486)

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protease; Secreted; Secreted, signal peptide; EC 3.4.23.15. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: extracellular space; cytoplasm; extracellular region; plasma membrane. Molecular Function: peptidase activity; insulin-like growth factor receptor binding; aspartic-type endopeptidase activity; receptor binding. Biological Process: response to cAMP; hormone-mediated signaling; renin-angiotensin regulation of aldosterone production; male gonad development; cell maturation; drinking behavior; response to lipopolysaccharide; angiotensin maturation; proteolysis; cellular protein metabolic process; regulation of MAPKKK cascade; regulation of blood pressure; beta-amyloid metabolic process; mesonephros development; kidney development. Disease: Renal Tubular Dysgenesis; Hyperuricemic Nephropathy, Familial Juvenile, 2

0.25 mg

410 USD