antibody

Renin antibody

MBS838098

0.25 mg

410 USD

monoclonal

mouse

nonconjugated

[M83161]

ELISA, radioimmunoassay, enzyme immunoassay

Antibody

Renin antibody

[Renin]

[Monoclonal Renin; Anti-Renin; FLJ10761; HNFJ2; REN; RENI; Renin; renin precursor renal; angiotensin-forming enzyme; Angiotensinogenase]

[renin preproprotein; Renin; renin; renin; Angiotensinogenase]

[REN; REN; HNFJ2]

RENI_HUMAN

Monoclonal

IgG1 kappa

[M83161]

Mouse

100% for active renin, <4% for Prorenin

406

Recognizes human Renin and Prorenin

Renin antibody was purified by urified by Protein A affinity chromatography

Purified unconjugated liquid in 0.1M BBS, pH 8.0, with no preservative

2.8 mg/ml

Store at 4°C

ELISA (EIA), Radioimmunoassay (RIA), Lateral Flow

MBS838098 can be used as the capture antibody in a matched pair immunoassay inconjunction with MBS838113 as the detection antibody

Immunogen: Human Recombinant renin

Proteases, Inhibitors, & Enzymes

Renin is an enzyme that participates in the body's renin-angiotensin system (RAS)-also known as the renin-angiotensin-aldosterone axis-that mediates extracellular volume (i.e., that the blood plasma, lymph and interstitial fluid), and arterial vasocontriction. Thus, it regulates the body's mean arterial blood pressure.

4506475

NP_000528.1

NM_000537.3

ACE Inhibitor Pathway (198763); Metabolism Of Angiotensinogen To Angiotensins Pathway (685555); Metabolism Of Proteins Pathway (106230); Peptide Hormone Metabolism Pathway (771603); Renin-angiotensin System Pathway (83075); Renin-angiotensin System Pathway (486)

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; EC 3.4.23.15; Secreted; Protease. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: extracellular space; cytoplasm; plasma membrane; extracellular region. Molecular Function: peptidase activity; insulin-like growth factor receptor binding; aspartic-type endopeptidase activity; receptor binding. Biological Process: response to cAMP; hormone-mediated signaling; male gonad development; renin-angiotensin regulation of aldosterone production; drinking behavior; cell maturation; response to lipopolysaccharide; proteolysis; angiotensin maturation; cellular protein metabolic process; regulation of MAPKKK cascade; regulation of blood pressure; beta-amyloid metabolic process; mesonephros development; kidney development. Disease: Renal Tubular Dysgenesis; Hyperuricemic Nephropathy, Familial Juvenile, 2

0.25 mg

410 USD