IGFBP3 antibody | MyBioSource MBS838032 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IGFBP3 antibody

catalog :

MBS838032

quantity :

0.5 mg

price :

815 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[M83104]

reactivity :

human

application :

ELISA, radioimmunoassay, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS838032

products type :

Antibody

products full name :

IGFBP3 antibody

products short name :

[IGFBP3]

products name syn :

[Monoclonal IGFBP3; Anti-IGFBP3; acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP-53; growth hormone-dependent binding protein; IBP-3; IBP3; IGF-binding protein 3; IGFBP-3; IGFBP3; insulin-like growth factor binding protein 3; Insulin-like growth factor-binding protein 3]

other names :

[insulin-like growth factor-binding protein 3 isoform a; Insulin-like growth factor-binding protein 3; insulin-like growth factor-binding protein 3; insulin-like growth factor binding protein 3]

products gene name :

[IGFBP3]

other gene names :

[IGFBP3; IGFBP3; IBP3; BP-53; IBP3; IBP-3; IGF-binding protein 3; IGFBP-3]

uniprot entry name :

IBP3_HUMAN

clonality :

Monoclonal

isotype :

IgG1 kappa

clone :

[M83104]

host :

Mouse

reactivity :

Recognizes natural and recombinant Human IgFBP-3

sequence length :

297

specificity :

Recognizes natural and recombinant Human IGFBP3

purity :

IGFBP3 antibody was purified by urified by Protein A affinity chromatography

form :

Liquid in 0.1 BBS,pH 8.0 with no preservatives.

concentration :

2.3 mg/mL

storage stability :

Ships on dry ice. Upon receipt store at -20°C . Avoid repeat freeze-thaw cycles.

tested application :

ELISA (EIA), Radioimmunoassay (RIA), Lateral Flow

app notes :

MBS838032 can be used as the detection antibody in a matched pair immunoassay inconjunction with MBS838129 as the capture antibody

other info2 :

Immunogen: Human recombinant IGFBP-3 . Biological Significance : IGFBP3 exerts antiproliferative effects in many cell types by blocking the ability of IGF-1 and IGF-2 to activate the IGFR1 (which stimulates cell profileration). For example, in esophageal epithelial cells, responsiveness to IGF-1 stimulation is suppressed by secreted IGFBP-3 and restored when IGFBP-3 is downregulated by epidermal growth factor.

products categories :

Cytokines & Growth Factors

products description :

Mouse Monoclonal IGFBP3 antibody

ncbi gi num :

62243248

ncbi acc num :

NP_001013416.1

ncbi gb acc num :

NM_001013398.1

ncbi mol weight :

32,223 Da

ncbi pathways :

Direct P53 Effectors Pathway (137939); Integrated Pancreatic Cancer Pathway (711360); Metabolism Of Proteins Pathway (106230); Myometrial Relaxation And Contraction Pathways (198759); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908); Senescence And Autophagy Pathway (198780); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987); P53 Signaling Pathway (83055); P53 Signaling Pathway (465)

ncbi summary :

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

uniprot summary :

IGFBP3: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Protein type: Secreted; Cell development/differentiation; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 7p12.3. Cellular Component: insulin-like growth factor binding protein complex; extracellular space; extracellular region; nucleus. Molecular Function: insulin-like growth factor binding; protein binding; insulin-like growth factor I binding; metal ion binding; fibronectin binding; insulin-like growth factor II binding; protein tyrosine phosphatase activator activity. Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of catalytic activity; regulation of insulin-like growth factor receptor signaling pathway; negative regulation of smooth muscle cell proliferation; apoptosis; positive regulation of apoptosis; negative regulation of smooth muscle cell migration; protein amino acid phosphorylation; positive regulation of myoblast differentiation; negative regulation of signal transduction; osteoblast differentiation; negative regulation of cell proliferation; cellular protein metabolic process; negative regulation of protein amino acid phosphorylation; positive regulation of MAPKKK cascade; regulation of cell growth

size1 :

0.5 mg

price1 :

815 USD

size2 :

1 mg

price2 :

1575

more info or order :

MyBioSource product webpage