catalog number :
MBS837826
products type :
Recombinant Protein
products full name :
CD4 protein
products short name :
CD4
products name syn :
CD 4; CD 4 protein; CD-4 protein; gp55 protein; soluble CD4 protein; sCD4 protein; L3 / T4 protein; T cell antigen T4/LEU3 protein; HLA-2 protein; CD-4; CD4; CD4mut protein; Ly-4 protein; T4 protein
other names :
CD4; CD4 protein; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD4 molecule; N/A
other gene names :
CD4; CD4; CD4mut; CD4 receptor
uniprot entry name :
Q13969_HUMAN
form :
Supplied lyophlized in 50mM MES, pH 6.0, 350 mM NaCl buffer
storage stability :
Store at 2-8 deg C, freeze reconstituted product in working aliquots at -70 deg C
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
ELISA: 1 ug/ml, WB: 1 ug/ml
products description :
Purified recombinant Human CD4 protein. CD4 is a cell-surface glycoprotein found on the mature helper T cells and immature thymocytes, as well as on monocytes and macrophages. (Some cytotoxic T cells have CD4 protein as well.) Normally, about 65% of T cells in the blood are CD4+ (have CD4 protein protruding from their membrane). A mature T cell with either have CD4 or CD8, but not both. During one stage of development T cells develop CD4 and CD8 receptors, but they eventually are differentiated in the thymus and become more specialized.
ncbi acc num :
CAA60883.1
ncbi mol weight :
7,844 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Alpha-defensins Pathway 530758!!Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!Arf1 Pathway 137927!!Binding And Entry Of HIV Virion Pathway 105986!!C-MYB Transcription Factor Network Pathway 138073!!CXCR4-mediated Signaling Events Pathway 137910!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480
ncbi summary :
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]