FGF1 protein | MyBioSource MBS837178 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

FGF1 protein

catalog :

MBS837178

quantity :

1 mg

price :

5295 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS837178

products type :

Recombinant Protein

products full name :

FGF1 protein

products short name :

FGF1

products name syn :

FGF 1; ACGFB protein; Prostatropin; Acidic Fibroblast Growth Factor; ECGF protein; FGF-1; HBGF-1 protein; FGFA protein; FGF 1 protein; ECGFA protein; FGF1; FGF-1 protein; Heparin-binding growth factor 1; AFGF protein

other names :

fibroblast growth factor 1 isoform 4; Fibroblast growth factor 1; fibroblast growth factor 1; fibroblast growth factor 1 (acidic); Acidic fibroblast growth factor; aFGF; Endothelial cell growth factor; ECGF; Heparin-binding growth factor 1; HBGF-1

products gene name :

FGF1

other gene names :

FGF1; FGF1; AFGF; ECGF; FGFA; ECGFA; ECGFB; FGF-1; HBGF1; HBGF-1; GLIO703; ECGF-beta; FGF-alpha; FGFA; FGF-1; aFGF; ECGF; HBGF-1

uniprot entry name :

FGF1_HUMAN

host :

Human

sequence length :

154

purity :

> 95% pure. FGF1 protein was purified by Heparin affinity chromatography

form :

Supplied in lyophilized form in 1 ml phosphate buffered saline (pH 6), supplemented with 5 mM glutathion

storage stability :

Store at 2-8 degree C in lyophilized form. Following reconstitution aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

User optimized

other info1 :

Protein Type: Recombinant. Biological Significance: This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. Bioactivity: < 3 ng/ml for half maximum stimulation of cell proliferation with bovine aortic endothelial cells (BAE cells)

other info2 :

Expression System: E Coli

products categories :

Cytokines & Growth Factors

products description :

Purified recombinant Human Acidic Fibroblast Growth Factor

ncbi gi num :

380748953

ncbi acc num :

NP_001244141.1

ncbi gb acc num :

NM_001257212.1

uniprot acc num :

P05230

ncbi mol weight :

20 kDa

ncbi pathways :

Activated Point Mutants Of FGFR2 Pathway (645281); Adaptive Immune System Pathway (366160); Constitutive Signaling By Aberrant PI3K In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764); Diseases Of Signal Transduction Pathway (1183518); Downstream Signal Transduction Pathway (106385); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250); Downstream Signaling Of Activated FGFR1 Pathway (1183557)

ncbi summary :

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

uniprot summary :

FGF1: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Cytokine. Chromosomal Location of Human Ortholog: 5q31. Cellular Component: nucleoplasm; proteinaceous extracellular matrix; extracellular space; extracellular region; nucleolus; cell cortex; cytosol. Molecular Function: heparin binding; protein binding; growth factor activity; Hsp70 protein binding; fibroblast growth factor receptor binding. Biological Process: epidermal growth factor receptor signaling pathway; anatomical structure morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; multicellular organismal development; positive regulation of cholesterol biosynthetic process; signal transduction; positive regulation of MAP kinase activity; positive regulation of angiogenesis; positive regulation of cell division; induction of an organ; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; positive regulation of epithelial cell proliferation; positive regulation of cell migration; lung development

size1 :

1 mg

price1 :

5295 USD

more info or order :

MyBioSource product webpage