catalog number :
MBS836406
products type :
Recombinant Protein
products full name :
CD4 protein
products short name :
CD4
products name syn :
CD4mut protein; CD 4 protein; sCD4 protein; CD-4 protein; T cell antigen T4/LEU3 protein; L3 / T4 protein; HLA-2 protein; Ly-4 protein; soluble CD4 protein; CD-4; T4 protein; CD 4; gp55 protein; CD4
other names :
CD4; CD4 protein; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD4 molecule; N/A
other gene names :
CD4; CD4; CD4mut; CD4 receptor
uniprot entry name :
Q13969_HUMAN
purity :
>95% by SDS-PAGE
storage stability :
Store lyophilized product at 2-8 deg C short term, following reconstitution, aliquot and store at -70 deg C or lower. Avoid repeated freeze/thaw cycles
products categories :
Immunology; Proteins; Native & Recombinant Proteins; Recombinant
products description :
Purified CD4 protein. CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene.
ncbi acc num :
CAA60883.1
ncbi mol weight :
7,844 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Alpha-defensins Pathway 530758!!Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!Arf1 Pathway 137927!!Binding And Entry Of HIV Virion Pathway 105986!!C-MYB Transcription Factor Network Pathway 138073!!CXCR4-mediated Signaling Events Pathway 137910!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480
ncbi summary :
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]