antibody

SGLT2 antibody

MBS835811

0.1 mg

560 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

Antibody

SGLT2 antibody

[SGLT2]

[Polyclonal SGLT2 antibody, anti-SGLT2 antibody, SGLT 2 antibody, SGLT2, SGLT-2 antibody, SGLT 2, SLC5A2 antibody, SGLT 2 antibody, SGLT-2, antibody, SLC5A 2 antibody, SGLT-2 antibody]

[sodium/glucose cotransporter 2; Sodium/glucose cotransporter 2; sodium/glucose cotransporter 2; solute carrier family 5 (sodium/glucose cotransporter), member 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2]

[SGLT2]

[SLC5A2; SLC5A2; SGLT2; SGLT2; Na(+)/glucose cotransporter 2]

SC5A2_HUMAN

Polyclonal

IgG

Rabbit

Human,Rat, Mouse

SGLT2 antibody was purified by affinity chromatography

Liquid in PBS containing 30% glycerol, 0.5% BSA, 5mM EDTA and 0.03% Proclin

0.5 mg/ml

Shipping: Blue Ice. Upon receipt store at -20°C short term. For long term storage, aliquot and store at -70°C. Avoid repeated freeze/thaw cycles.

Suitable for use in Western Blot (WB).

Western Blot: 0.5-4 ug/ml, however the optimal concentrations should be determined individually

Western Blot (WB)

Assay Information: Biological Significance: Sodium glucose co transporters are located in the brush-border membrane, but transported out of the cell across the basolateral membranes by a facilitated sugar transporter. At least three members of SGLTs have been cloned and characterized. SGLTs transport a methyl-D-glucoside, a non-metabolized model substrate, in Na-dependent manner. SGLT-1 does not discriminate a-MDG, glucose, and galactose. SGLT2/3 do not transport D-galactose efficiently.

Immunogen: Synthetic peptide near the N-terminus of mouse SGLT-2

Nutrition & Metabolism; Purified Polyclonal Antibodies

Rabbit polyclonal SGLT2 antibody

4507033

NP_003032.1

NM_003041.3

P31639

Hexose Transport Pathway (106198); Inositol Transporters Pathway (119575); Metabolism Pathway (477135); Metabolism Of Carbohydrates Pathway (106196); Na+-dependent Glucose Transporters Pathway (119574); SLC-mediated Transmembrane Transport Pathway (119558); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (119571)

This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]

SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: plasma membrane; integral to membrane. Molecular Function: low-affinity glucose:sodium symporter activity. Biological Process: transport; carbohydrate metabolic process; sodium ion transport; glucose transport; transmembrane transport. Disease: Renal Glucosuria

0.1 mg

560 USD