PAD4 antibody | MyBioSource MBS835768 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PAD4 antibody

catalog :

MBS835768

quantity :

0.1 mL

price :

515 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS835768

products type :

Antibody

products full name :

PAD4 antibody

products short name :

PAD4

products name syn :

Polyclonal PAD4; Anti-PAD4; peptidyl arginine deiminase type V; PADI5; PAD 4; protein-arginine deiminase type IV; PDI5; HL-60 PAD; PADI4; PAD-4; PADI-H protein; protein-arginine deiminase type-4; PDI4; PAD4; PAD

other names :

protein-arginine deiminase type-4; Protein-arginine deiminase type-4; protein-arginine deiminase type-4; peptidyl arginine deiminase, type IV; HL-60 PAD; Peptidylarginine deiminase IV; Protein-arginine deiminase type IV

products gene name :

PAD4

other gene names :

PADI4; PADI4; PAD; PAD4; PDI4; PDI5; PADI5; PADI5; PDI5

uniprot entry name :

PADI4_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

663

purity :

PAD4 antibody was purified by antigen-affinity chromatography

form :

Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.

concentration :

0.73 mg/ml

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

app notes :

IF:1:100-1:500. ICC:1:100-1:500. IHC-P: 1:100-1:500. WB: 1:500-1:3000

other info1 :

Biological Significance: This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.

products categories :

Proteases, Inhibitors, Purified Polyclonal Antibodies

products description :

Affinity purified Rabbit polyclonal PAD4 antibody

ncbi gi num :

216548487

ncbi acc num :

NP_036519.2

ncbi gb acc num :

NM_012387.2

uniprot acc num :

Q9UM07

ncbi mol weight :

74 kDa

ncbi pathways :

Protein Citrullination Pathway (142167); Protein Citrullination Pathway (138213)

ncbi summary :

This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]

uniprot summary :

PADI4: Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at Arg-8 and/or Arg-17 and histone H4 at Arg-3 , which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at Arg-2142 , which favors its interaction with NCOA2/GRIP1. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context. Belongs to the protein arginine deiminase family. Protein type: Nuclear receptor co-regulator; Hydrolase; EC 3.5.3.15. Chromosomal Location of Human Ortholog: 1p36.13. Cellular Component: cytoplasm; nucleus. Molecular Function: arginine deiminase activity; protein binding; calcium ion binding; protein-arginine deiminase activity. Biological Process: chromatin remodeling; nucleosome assembly; regulation of transcription, DNA-dependent; transcription, DNA-dependent; stem cell maintenance; protein modification process; innate immune response; chromatin modification; peptidyl-citrulline biosynthetic process from peptidyl-arginine. Disease: Rheumatoid Arthritis

size1 :

0.1 mL

price1 :

515 USD

more info or order :

MyBioSource product webpage