Complement C1q antibody (FITC) | MyBioSource MBS835525 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Complement C1q antibody (FITC)

catalog :

MBS835525

quantity :

5 mL

price :

215 USD

clonality :

polyclonal

host :

goat

conjugate :

FITC

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS835525

products type :

Antibody

products full name :

Complement C1q antibody (FITC)

products short name :

Complement C1q

products name syn :

Polyclonal Complement C1q; Anti-Complement C1q; Complement Cq-1; Complement C1q; Complement Cq 1; C1q

other names :

complement C1q subcomponent subunit C; Complement C1q subcomponent subunit C; complement C1q subcomponent subunit C; complement component 1, q subcomponent, C chain

other gene names :

C1QC; C1QC; C1QG; C1Q-C; C1QG

uniprot entry name :

C1QC_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Monoprecipitin arc versus normal Human plasma and 2x concentRated normal Human serum.

sequence length :

245

specificity :

Human complement C1q

form :

Supplied as delipidated, defibrinated and 0.2 um filtered in 0.2M Tris, pH 7.4, with 0.5M NaCl and 0.1% NaN3.

concentration :

Molar F/P ratio: 3.43.

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

User optimized

other info1 :

Biological Significance: Complement C1q is part of the C1 complex and this complex is the first complement component in the cascade referred to as the classical pathway of complement. C1 is actually a non-covalent assembly of three different proteins (C1q, C1r, and C1s) bound together in a calcium-dependent complex. C1q has six extended arms with domains at the end of each arm that bind to the Fc domains of immunoglobulins.

other info2 :

Tag/Conjugate: FITC. Immunogen: Complement C1q antibody was raised in goat using human complement C1q as the immunogen.

products categories :

Immunology; Conjugated Polyclonal Antibodies

products description :

Goat polyclonal Human Complement C1q antibody (FITC)

ncbi gi num :

166235903

ncbi acc num :

NP_001107573.1

ncbi gb acc num :

NM_001114101.1

uniprot acc num :

P02747

ncbi mol weight :

25,774 Da

ncbi pathways :

Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Classical Antibody-mediated Complement Activation Pathway (106409); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); Immune System Pathway (106386)

ncbi summary :

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1p36.11. Cellular Component: extracellular space; collagen; extracellular region. Biological Process: negative regulation of macrophage differentiation; innate immune response; immune response; complement activation, classical pathway; complement activation; negative regulation of granulocyte differentiation. Disease: C1q Deficiency

size1 :

5 mL

price1 :

215 USD

more info or order :

MyBioSource product webpage