catalog number :
MBS835436
products full name :
SP140 antibody
products short name :
SP140
products name syn :
Polyclonal SP140; Anti-SP140; SP 140; SP-140; SP140 nuclear body protein; SP140
other names :
nuclear body protein SP140 isoform 2; Nuclear body protein SP140; nuclear body protein SP140; SP140 nuclear body protein; Lymphoid-restricted homolog of Sp100
products gene name :
SP140
other gene names :
SP140; SP140; LYSP100; LYSP100-A; LYSP100-B; LYSp100
uniprot entry name :
SP140_HUMAN
reactivity :
Human, Mouse, Rat, Dog
form :
Lyophilized powder. Add 100 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
storage stability :
Store at 4 degree C, following reconstitution, aliquot and store at -20 degree C. Avoid repeated freeze-thaw cycles.
tested application :
Immunohistochemistry (IHC), Western Blot (WB)
app notes :
Optimal conditions to be determined by the end user
other info1 :
Biological Significance: SP140 is the nuclear body protein found specifically in all NP cells. HIV-1 infection induced its partial dispersal from nuclear bodies into cytosolic colocalization with Vif.
other info2 :
Immunogen: SP140 antibody was raised in rabbit using the N terminal of SP140 as the immunogen
products categories :
Signal Transduction
products description :
Rabbit polyclonal SP140 antibody
ncbi acc num :
NP_001005176
ncbi gb acc num :
NM_001005176.2
ncbi mol weight :
91,673 Da
uniprot summary :
SP140: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 2q37.1. Cellular Component: nucleoplasm; PML body; cytoplasm; nuclear envelope; nucleus. Molecular Function: protein binding; DNA binding; zinc ion binding; chromatin binding; transcription factor activity. Biological Process: chromatin remodeling; regulation of transcription, DNA-dependent; defense response