RAMP2 antibody | MyBioSource MBS834998 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RAMP2 antibody

catalog :

MBS834998

quantity :

0.1 mL

price :

585 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4.00E+05

reactivity :

human

application :

western blot, immunohistochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS834998

products type :

Antibody

products full name :

RAMP2 antibody

products short name :

RAMP2

products name syn :

Monoclonal RAMP2; Anti-RAMP2; RAMP2; RAMP 2; RAMP-2

other names :

receptor activity-modifying protein 2; Receptor activity-modifying protein 2; receptor activity-modifying protein 2; receptor (G protein-coupled) activity modifying protein 2; Calcitonin-receptor-like receptor activity-modifying protein 2; CRLR activity-modifying protein 2

products gene name :

RAMP2

other gene names :

RAMP2; RAMP2; CRLR activity-modifying protein 2

uniprot entry name :

RAMP2_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

4.00E+05

host :

Mouse

reactivity :

Human

sequence length :

175

purity :

RAMP2 antibody was purified by affinity chromatography.

form :

Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.

concentration :

0.5-1 mg/ml

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Western Blot (WB)

app notes :

FC: 1:100. IHC: 1:150. WB: 1:1000

other info1 :

Biological Significance: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor.

other info2 :

Immunogen: RAMP2 antibody was raised in Mouse using full length human recombinat protein of human RAMP2 produced in HEK293T cell as the immunogen.

products categories :

Protein Modification & Stress Response

products description :

Mouse monoclonal RAMP2 antibody

ncbi gi num :

118572585

ncbi acc num :

NP_005845.2

ncbi gb acc num :

NM_005854.2

uniprot acc num :

O60895

ncbi mol weight :

20,063 Da

ncbi pathways :

Calcitonin-like Ligand Receptors Pathway (106379); Class B/2 (Secretin Family Receptors) Pathway (106378); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Myometrial Relaxation And Contraction Pathways (198759); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356); Vascular Smooth Muscle Contraction Pathway (96530); Vascular Smooth Muscle Contraction Pathway (96866)

ncbi summary :

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]

uniprot summary :

RAMP2: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Belongs to the RAMP family. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 17q12-q21.1. Cellular Component: cell surface; integral to plasma membrane; lysosome; cytoplasm; plasma membrane; coated pit; receptor complex. Molecular Function: protein binding; coreceptor activity; protein transporter activity. Biological Process: heart development; female pregnancy; response to estradiol stimulus; cellular response to hormone stimulus; G-protein coupled receptor protein signaling pathway; intracellular protein transport; protein transport; positive regulation of angiogenesis; regulation of blood pressure; calcium ion transport; receptor internalization; positive regulation of cAMP biosynthetic process; response to hypoxia; negative regulation of vascular permeability; cAMP biosynthetic process; angiogenesis; sprouting angiogenesis; response to progesterone stimulus; vasculogenesis; regulation of G-protein coupled receptor protein signaling pathway

size1 :

0.1 mL

price1 :

585 USD

more info or order :

MyBioSource product webpage