Merlin antibody | MyBioSource MBS834964 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Merlin antibody

catalog :

MBS834964

quantity :

0.1 mL

price :

375 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[AF1G4]

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS834964

products type :

Antibody

products full name :

Merlin antibody

products short name :

[Merlin]

products name syn :

[Monoclonal Merlin; Anti-Merlin; NF2; neurofibromin 2 (merlin); acn; banf; BOS_16741; merlin; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromatosis 2; neurofibromin 2; neurofibromin-2; neurofibromin 2 (bilateral acoustic neuroma); RCJMB04_19i21; RP23-280J3.6; SCH; schwannomerlin; schwannomin]

other names :

[merlin isoform 7; Merlin; merlin; neurofibromin 2 (merlin); Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin]

other gene names :

[NF2; NF2; ACN; SCH; BANF; SCH]

uniprot entry name :

MERL_HUMAN

clonality :

Monoclonal

isotype :

IgG2a/k

clone :

[AF1G4]

host :

Mouse

reactivity :

Human, Mouse, Rat

sequence length :

507

purity :

Merlin antibody was purified by ammonium sulfate precipitation

form :

Protein G purified liquid in HEPES with 150 mM NaCI, 0.01% BSA, 0.03% NaN 3 , and 50% glycerol.

concentration :

1.0 mg/mL

storage stability :

Store at 4°C, -20°C for 1 year from date of shipment.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

WB: 1:2000

image1 heading :

Western Blot (WB)

other info1 :

Biological Significance: Merlin is a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve.

other info2 :

Immunogen: Recombinant human protein purified from E.coli (His-Merlin)

products categories :

Neuroscience

products description :

Mouse monoclonal Merlin antibody

ncbi gi num :

32967514

ncbi acc num :

NP_861969.1

ncbi gb acc num :

NM_181831.2

uniprot acc num :

P35240

ncbi pathways :

ErbB2/ErbB3 Signaling Events Pathway (137955); Hippo Signaling Pathway (1084759); Hippo Signaling Pathway (1108222); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); RHO GTPase Effectors Pathway (1183584); RHO GTPases Activate PAKs Pathway (1183586); Signal Transduction Pathway (477114); Signaling By Rho GTPases Pathway (106502)

ncbi summary :

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]

uniprot summary :

Merlin: a moesin-ezrin-radizin-like protein. Interacts with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. Expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations are associated with neurofibromatosis type II. Two predominant isoforms and eight minor isoforms are produced by alternatively spliced transcripts. Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor. Chromosomal Location of Human Ortholog: 22q12.2. Cellular Component: filopodium membrane; cortical actin cytoskeleton; early endosome; cytoskeleton; extrinsic to membrane; adherens junction; membrane; lamellipodium; perinuclear region of cytoplasm; apical part of cell; cytoplasm; plasma membrane; nucleolus; nucleus; cleavage furrow. Molecular Function: protein binding; actin binding. Biological Process: intercellular junction assembly and maintenance; negative regulation of MAPKKK cascade; hippocampus development; regulation of protein stability; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of cell-matrix adhesion; odontogenesis of dentine-containing teeth; Schwann cell proliferation; negative regulation of cell proliferation; mesoderm formation; negative regulation of DNA replication; positive regulation of stress fiber formation; negative regulation of tyrosine phosphorylation of Stat3 protein; ectoderm development; negative regulation of protein kinase activity; negative regulation of cell-cell adhesion; actin cytoskeleton organization and biogenesis; positive regulation of cell differentiation; negative regulation of JAK-STAT cascade; negative regulation of cell migration. Disease: Meningioma, Familial, Susceptibility To; Neurofibromatosis, Type Ii; Schwannomatosis 1

size1 :

0.1 mL

price1 :

375 USD

more info or order :

MyBioSource product webpage