DR3 antibody | MyBioSource MBS834956 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

DR3 antibody

catalog :

MBS834956

quantity :

0.1 mg

price :

380 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[JD3]

reactivity :

human

application :

immunohistochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS834956

products type :

Antibody

products full name :

DR3 antibody

products short name :

[DR3]

products name syn :

[Monoclonal DR3; Anti-DR3; Apo-3; Tyrosine-rich acidic matrix protein; TRAIL Receptor family; DR 3; DR-3; DR3; TRAMP]

other names :

[DR3; Tumor necrosis factor receptor superfamily member 25; tumor necrosis factor receptor superfamily member 25; tumor necrosis factor receptor superfamily, member 25; Apo-3; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; Death receptor 3; Lymphocyte-associated receptor of death; LARD; Protein WSL; Protein WSL-1]

products gene name :

[DR3]

other gene names :

[TNFRSF25; TNFRSF25; DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12; APO3; DDR3; DR3; TNFRSF12; WSL; WSL1; LARD]

uniprot entry name :

TNR25_HUMAN

clonality :

Monoclonal

isotype :

IgG1 kappa

clone :

[JD3]

host :

Mouse

reactivity :

Human

sequence length :

417

purity :

DR3 antibody was purified by affinity chromatography.

form :

Affinity purified supplied as liquid in PBS, pH 7.2, with 0.09% NaN 3

concentration :

0.5 mg/ml

storage stability :

Store at 4°C. Do not freeze. Protect from light.

tested application :

Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)

app notes :

A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal /formance in the assay of interest

other info1 :

Biological Significance: The JD3 monoclonal antibody reacts with human DR3, also known as Apo-3, WSL-1, TRAMP, LARD, DDR3, and TR3. DR3, a novel death receptor is expressed at low level by monocytes and granulocytes. Interaction of DR3 with its ligand activates NF-kappaB pathway and induces apoptosis. Initially, DR3 was thought to be a receptor for TWEAK, but further studies have shown that TWEAK could induce apoptosis via receptors distinct from DR3. JD3 has been reported for use in flow cytometric analysis.

products categories :

Cell Cycle & Cell Death

products description :

Mouse monoclonal DR3 antibody

ncbi gi num :

37181738

ncbi acc num :

AAQ88676.1

uniprot acc num :

Q93038

ncbi mol weight :

29,111 Da

ncbi pathways :

Apoptosis Pathway (198797); Apoptosis Modulation And Signaling Pathway (198822); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460)

ncbi summary :

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]

uniprot summary :

TNFRSF25: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4. Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate. 12 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, misc.; Apoptosis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p36.2. Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; cytosol. Molecular Function: tumor necrosis factor receptor activity; receptor activity. Biological Process: regulation of apoptosis; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; apoptosis; signal transduction

size1 :

0.1 mg

price1 :

380 USD

more info or order :

MyBioSource product webpage