14-3-3 beta antibody | MyBioSource MBS834603 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

14-3-3 beta antibody

catalog :

MBS834603

quantity :

0.1 ml

price :

395 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

60C10

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS834603

products type :

Antibody

products full name :

14-3-3 beta antibody

products short name :

14-3-3 beta

products name syn :

Monoclonal 14-3-3 beta; Anti-14-3-3 beta; YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein; beta polypeptide; 14-3-3 alpha; 14-3-3beta; 14.3.3 beta; 14-3-3 protein beta; 14-3-3 protein beta/alpha; 14-3-3 protein beta-subtype; 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide; BOS_13300; brain protein 14-3-3; beta isoform; gw128; HS1; kcip-1; prepronerve growth factor RNH-1; protein 1054; protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; RCJMB04_5d11; RP1-148E22.1; RP23-321M14.1; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; TTpA010k20.1; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein; alpha polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein; YWHAA

other names :

14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1

products gene name :

14-3-3 beta

other gene names :

YWHAB; YWHAB; HS1; GW128; YWHAA; KCIP-1; HEL-S-1; KCIP-1

uniprot entry name :

1433B_HUMAN

clonality :

Monoclonal

isotype :

IgG2b kappa

clone :

60C10

host :

Mouse

reactivity :

Human, Mouse, Rat

sequence length :

246

purity :

14-3-3 beta antibody was purified by ammonium sulfate precipitation

form :

Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

storage stability :

Aliquot and store for 1 year at -20 degree C, avoid freeze/thaw cycles

tested application :

Western Blot (WB)

app notes :

WB: 1:2000

other info1 :

Biological Significance: 14-3-3, a family of acidic and soluble proteins, highly conserved in amino acid sequences from yeast to mammals, is expressed in all eukaryotic cells. Seven isoforms (beta, gamma, epsilon, eta, zeta, omega and t/?) encoded by seven distinct genes are identified in mammals and forms homo- and hetero- dimeric cup-shaped structures. As 14-3-3 is interacted with more than 100 binding partners, it regulates key proteins involved in various biological processes such as signal trans-duction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology. Most 14-3-3 requires phosphorylation of serine or threonine residues in the target sequence. This protein is abundantly expressed in the brain and has been detected in the cerebrospinal fluid of patients with different neurological disorders.

other info2 :

Immunogen: 14-3-3 beta antibody was raised in Mouse using a recombinant human protein purified from E Coli as the immunogen

products categories :

Neuroscience

products description :

Mouse monoclonal 14-3-3 beta antibody

ncbi gi num :

21328448

ncbi acc num :

NP_647539.1

ncbi gb acc num :

NM_139323.3

uniprot acc num :

P31946

ncbi mol weight :

27,850 Da

ncbi pathways :

ARMS-mediated Activation Pathway 106466!!Activation Of BAD And Translocation To Mitochondria Pathway 105659!!Activation Of BH3-only Proteins Pathway 105658!!Adaptive Immune System Pathway 366160!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Apoptosis Pathway 105648!!Axon Guidance Pathway 105688!!Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway 187213!!Calcium Regulation In The Cardiac Cell Pathway 198906!!Cell Cycle Pathway 530733

ncbi summary :

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

size :

0.1 ml

price :

395 USD

more info or order :

MyBioSource product webpage