catalog number :
MBS834528
products full name :
TMOD1 antibody
products short name :
[TMOD1]
products name syn :
[Monoclonal TMOD1; Anti-TMOD1; D9S57E; ETMOD; TMOD; TMOD1; TMOD 1; TMOD-1]
other names :
[tropomodulin-1; Tropomodulin-1; tropomodulin-1; tropomodulin 1; Erythrocyte tropomodulin; E-Tmod]
products gene name :
[TMOD1]
other gene names :
[Tmod1; Tmod1; Tmod; E-Tmod; Tmod; E-Tmod]
uniprot entry name :
TMOD1_MOUSE
reactivity :
Human, Rat, Monkey, Mouse
purity :
TMOD1 antibody was purified by affinity chromatography.
form :
Liquid in PBS, pH 7.3 with 1% BSA, 50% Glycerol and 0.02% NaN 3
concentration :
0.86 mg/ml
storage stability :
Shipping: Blue ice. Upon receipt store at -20°C. Avoid freeze/thaw cycles.
tested application :
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
IF: 1:100. IHC: 1:150. WB: 1:500-2000
image1 heading :
Immunofluorescence (IF)
image2 heading :
Western Blot (WB)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Biological Significance: This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton.
other info2 :
Immunogen: Full length human recombinant protein of human TMOD1 produced in HEK293T cell.
products categories :
Cell Biology
products description :
Mouse monoclonal TMOD1 antibody
ncbi acc num :
NP_068683.1
ncbi gb acc num :
NM_021883.2
ncbi pathways :
Muscle Contraction Pathway (1168140); Striated Muscle Contraction Pathway (1168141); Striated Muscle Contraction Pathway (198348)
uniprot summary :
TMOD1: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. Belongs to the tropomodulin family. Protein type: Cytoskeletal; Cell development/differentiation; Motility/polarity/chemotaxis; Contractile. Cellular Component: cortical cytoskeleton; signalosome; sarcomere; cytoskeleton; membrane; myofibril; cytoplasm; nucleus; striated muscle thin filament. Molecular Function: actin filament binding; tropomyosin binding; actin binding. Biological Process: muscle thick filament assembly; myofibril assembly; muscle contraction; adult locomotory behavior; actin filament organization; pointed-end actin filament capping