antibody

PD1 antibody

MBS833799

0.05 mg

240 USD

monoclonal

hamsters

nonconjugated

[J43]

human, mouse

immunohistochemistry, immunoprecipitation, flow cytometry

Antibody

PD1 antibody

[PD1]

[Monoclonal PD1; Anti-PD1; PD 1; PD1; PD-1]

[programmed cell death protein 1; Programmed cell death protein 1; programmed cell death protein 1; programmed cell death 1; CD_antigen: CD279]

[PD1]

[PDCD1; PDCD1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; PD1; Protein PD-1; hPD-1]

PDCD1_HUMAN

Monoclonal

IgG

[J43]

Armenian Hamster

Mouse

288

PD1 antibody was purified by affinity chromatography.

Liquid in PBS, PH 7.2, with 0.09% sodium azide

0.5 mg/ml

Store at 4°C

FC, IHC, IP

Flow Cytometry (FC/FACS)

Biological Significance: The J43 monoclonal antibody reacts with mouse PD-1, a 55 kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 and PD-L2. Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. It is reported that J43 inhibits the binding of mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1/BHK transfected cells. When administrated in vivo, both intact and Fab of J43 are reported to enhance contact hypersensitivity and exacerbate acute GVHD similar to transfer of PD-1-deficient cells. Injection of J43 also exacerbates EAE and NOD diabetes as do specific antibodies to mouse PD-L1 and PD-L2.

Cell Cycle & Cell Death

Armenian Hamster monoclonal PD1 antibody

167857792

NP_005009.2

NM_005018.2

31,647 Da

Adaptive Immune System Pathway (366160); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (119552); Immune System Pathway (106386); PD-1 Signaling Pathway (119557); T Cell Receptor Signaling Pathway (83080); T Cell Receptor Signaling Pathway (491)

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse exhausted T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells. Protein type: Apoptosis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q37.3. Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane. Molecular Function: signal transducer activity; protein binding. Biological Process: apoptosis; multicellular organismal development; T cell costimulation; signal transduction; humoral immune response. Disease: Systemic Lupus Erythematosus

0.05 mg

240 USD

0.1 mg

305