IRF6 antibody | MyBioSource MBS833745 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IRF6 antibody

catalog :

MBS833745

quantity :

0.1 mL

price :

725 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[2A12]

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry

more info or order :

MyBioSource product webpage

image

image 1 :

Flow Cytometric analysis of HEK293T cells transfected with either recombinant IRF6 protein (red) or empty vector (blue) stained using IRF6 antibody

image 2 :

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant IRF6 protein (Right) or empty vector (Left) detected with IRF6 antibody

image 3 :

Immunohistochemical analysis of IRF6 protein in paraffin embedded Human Kidney tissue using IRF6 antibody

product information

catalog number :

MBS833745

products type :

Antibody

products full name :

IRF6 antibody

products short name :

[IRF6]

products name syn :

[Monoclonal IRF6 antibody, Anti-IRF6 antibody, Interferon Regulatory Factor 6 antibody, LPS antibody, OFC6 antibody, PIT antibody, PPS antibody, VWS antibody, IRF6, IRF 6, IRF-6, IRF 6 antibody, IRF-6 antibody]

other names :

[interferon regulatory factor 6 isoform 1; Interferon regulatory factor 6; interferon regulatory factor 6; interferon regulatory factor 6]

products gene name :

[IRF6]

other gene names :

[IRF6; IRF6; LPS; PIT; PPS; VWS; OFC6; PPS1; VWS1; IRF-6]

uniprot entry name :

IRF6_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

clone :

[2A12]

host :

Mouse

reactivity :

Reacts with Human

sequence length :

467

purity :

IRF6 antibody was purified by affinity chromatography.

form :

Liquid in PBS, pH 7.3 containing 1% BSA, 50% Glycerol and 0.02% sodium azide.

concentration :

0.2 mg/mL

storage stability :

Shipping: Blue ice . Upon receipt store -20°C.

tested application :

WB,IHC,IF,FLOW.

app notes :

WB (1/2000). IHC (1/150). IF (1/100). FLOW (1/100)

image1 heading :

Flow Cytometric FC

image2 heading :

Western Blot (WB)

image3 heading :

Immunohistochemistry (IHC)

image4 heading :

Immunofluorescence (IF)

image4 description :

Immunofluorescent staining of COS7 cells transiently transfected with recombinant IRF6 protein using IRF6 antibody

other info1 :

Biological Significance: IRF6 is a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. Mutations in its gene can cause van der Woude syndrome and popliteal pterygium syndrome. This protein is involved in palate formation.

other info2 :

Immunogen: Purified from mouse ascites fluid by affinity chromatography.

products categories :

Cytokines & Growth Factors

products description :

Mouse monoclonal IRF6 antibody

ncbi gi num :

5453700

ncbi acc num :

NP_006138

ncbi gb acc num :

NM_006147.3

uniprot acc num :

O14896

ncbi pathways :

Apoptosis Pathway (198797); Cytokine Signaling In Immune System Pathway (366171); Immune System Pathway (106386); Interferon Signaling Pathway (187103); Interferon Alpha/beta Signaling Pathway (187104); Interferon Gamma Signaling Pathway (187106)

ncbi summary :

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]

uniprot summary :

IRF6: Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Interacts with SERPINB5. Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. Belongs to the IRF family. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 1q32.3-q41. Cellular Component: cytoplasm; cytosol; nucleus. Molecular Function: protein binding; DNA binding; transcription factor activity. Biological Process: keratinocyte differentiation; negative regulation of cell proliferation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; keratinocyte proliferation; cell cycle arrest; cell development. Disease: Orofacial Cleft 6, Susceptibility To; Popliteal Pterygium Syndrome; Van Der Woude Syndrome 1

size1 :

0.1 mL

price1 :

725 USD

more info or order :

MyBioSource product webpage